Acquaintance With Acomplia Obesity Today Generic Acomplia Tomorrow
Obesity Today, Generic Acomplia Tomorrow
Obesity is considered to be one of the most common metabolic diseases. This disease is characterized by excessive fat deposition in the subcutaneous tissue and other tissues of the body, the excess of the normal body weight on 20% or more. Statistical data of the insurance companies undeniably testify that obesity is associated with a significantly increased mortality from a number of serious diseases. The mortality of women with obesity is 147% and of men - 150% from the normal, and obesity in especially increases the mortality from heart disease (142% for men and 175% for women), strokes (159% for men and 162% for women), nephritis (191% for men and 211% for women), diabetes (383% for men and 372% for women) and liver cirrhosis (249% for men and 147% for women).
In addition, obesity is usually associated with overeating while leanness with beauty and the right way of life. Obesity has hard psychological consequences, especially for women and young people. Studies conducted by Mayer and his colleagues at Harvard University have shown that obese adolescent girls have the same psychological characteristics as persons belonging to minorities that are discriminated. Obese young girls are not only overly concerned about their condition but they are characterized as passive and experience fear of hostile attitude. These concerns are supported by real manifestations of antipathy from others.
But nowadays there are so many ways to fight with obesity! We offer you to learn the information about such preparation as Acomplia. You can order Acomplia at our online med store today!
The pharmacological properties of Generic Acomplia
Rimonabant is a selective antagonist of the cannabinoid-1 receptor (KB1), which inhibits the pharmacological effects of cannabinoid agonists in in vivo and in vitro studies. Endokannabinoid system is present in the brain and peripheral tissues (including adipocytes) and affects glucose and lipid metabolism, energy balance and body weight. And it also controls the consumption of food in neurons of the mesolimbic system.
The pharmacokinetics of Acomplia changes proportionally to a certain extent and depends on a dose (till 20 mg). AUC was increasing less proportionally according to a dose (above 20 mg). You can buy Acomplia at our online pharmacy.
The greatest weight loss with generic Acomplia was observed during the first nine months of treatment. Acomplia in a dose of 20 mg was effective in maintaining the reduction of the body weight for up to two years. Loss of body weight in patients receiving Acomplia in a dose of 20 mg for two years was 5.1 kg and 1.2 kg in patients from the placebo group (difference is 3.8 kg).
According to the studies, Acomplia reduces the risk of the weight recovery. Those patients, who received the drug for one year, were re-randomized into Acomplia or placebo groups. After two years, patients who continued the treatment with Acomplia lost in average 7.5 kg of body weight for 2 years, whereas patients who were re-randomized to placebo group in average lost 3.1 kg of the body weight. For two years, the difference of the total body weight loss in the group of patients taking Acomplia in comparison with the placebo group was -4.2 kg. The treatment with Acomplia showed a significant reduction in waist circumference, which is a known indicator of intra-abdominal fat. You can order Acomplia at our online pharmacy.
Effect on body weight is obviously the same among men and women. Conclusions about efficacy in patients older than 75 years or representatives of Asian race cannot be done due to the small number of patients.
In elderly patients the duration of Acomplia’s work is slightly higher than in younger patients. On the basis of the population pharmacokinetic analysis (the age group 18-81 years) patients in the age of 75 years can have a maximum plasma concentration higher on 21% and AUC on 27% higher than the 40-year-old patient. Order Acomplia right now at our online pharmacy.
Results of the six-month study, called Serenade, were announced at the International Congress of the Diabetes Study, held in Cape Town. The study involved 278 participants suffering from the 2nd type of diabetes, which did not use any drugs. The main property of the study is that Acomplia can greatly improve the level of sugar in the blood, thus bringing it back to normal in patients with the 2nd type of diabetes at the same time helping them to reduce their weight. You can easily buy Acomplia at our online med store.
Acomplia has no unpleasant or long side effects. Some patients may experience a short-term nervousness, hypererethism, insomnia or mild depression. It is believed that such phenomena are permittable for the drugs that affect the brain receptors.
It is also important to remember that Acomplia is not a panacea against overweight and you should not fight with obesity only with the help of this preparation. It should be applied in conjunction with dietary and physical activity. Buy Acomplia today at our online pharmacy!
Patients with hepatic impairment and Generic Acomplia
Mild liver dysfunction does not change the pharmacokinetics of Acomplia. There is not enough data to draw conclusions regarding the pharmacokinetics in patients with moderate hepatic impairment. Evaluation of pharmacokinetics in patients with severe hepatic impairment was not performed.
Patients with renal insufficiency and Generic Acomplia
The influence of kidney function on the pharmacokinetics of Acomplia was not specifically studied. On the basis of the data obtained as a result of population pharmacokinetic studies, mild and moderate renal impairment did not affect the pharmacokinetics of Acomplia. Limited data indicate an increase in the duration of Acomplia’s action in patients with moderate renal impairment (AUC increased by 40%).