Amoxicillin and Clavulanate (Augmentin 375 mg)
More facts about Generic Amoxicillin and Clavulanate (Augmentin 375 mg):
Generic Amoxicillin and Clavulanate (Augmentin 375 mg) guide:
What is Generic Amoxicillin plus Clavulanate?
The medication you can find looking for Generic Amoxicillin plus Clavulanate is an antibiotic based on two active substances indicated in the name of the drug. It is a combination antibacterial medication. Amoxicillin is a semi-synthetic antibiotic of a broad spectrum of action which belongs to a group of penicillins. By its pharmacological properties is similar to Ampicillin, but has better bioavailability when taken orally.
Clavulanate is an acid with the antibacterial effect which is not very effective alone but in combination with the penicillins it provides perfect effect - it prevents resistance development in bacteria to the main antibiotic used for the therapy.
The brand name of the medication sold in the U.S. and some other countries is Amoxicillin and Clavulanate. But the drug is also available under other trade names such as, for example, Augmentin.
Is the medication different from the brand-name medication?
Although generics are manufactured by other pharmaceutical companies, before they are approved for the marketing, they are tested for the compliance with the original composition and formula. Generics and especially generic antibiotics are promoted by the World Health Organization as a part of the program aimed to make essential medicines available to everyone. However, not all generics are the same. Some unscrupulous manufacturers use inferior materials for their drugs or use an insufficient amount of the active substance per pill. But do not worry – when you buy Augmentin from Rxshop, you will receive the antibiotic drug identical to the original Amoxicillin and Clavulanate. We check the quality, certificates, and reputation of the generics we sell before we offer them at our online drugstore. You can find the reviews left by our satisfied customers on the product pages and other websites.
When should Generic Amoxicillin and Clavulanate be used?
Antibiotics are used to treat bacterial infections. This particular drug is used for a variety of respiratory and urinary tract infections susceptible to Amoxicillin. If you are not diagnosed with a bacterial but a viral infection, you need to take antiviral medications. If you are diagnosed with a bacterial infection and your doctor prescribed you another antibiotic based on your susceptibility tests, you need to buy namely that drug or its generic.
How to use the medication?
Buy Generic Amoxicillin and Clavulanate only if your susceptibility test shows that the infection you have is sensitive to this antibiotic and use the medication either as your doctor recommends or following this instruction:
Use of the medication in adults:
- Aspiration Pneumonia: the drug should be taken by 500 mg two times a day with an interval of 8 hours or by 875 mg once a day (every 12 hours). The treatment course duration is established by the doctor on the basis of the disease dynamics. It can take up to 4 month.
- Pneumonia: the drug should be taken by 500 mg two times a day with an interval of 8 hours or by 875 mg once a day (every 12 hours). The treatment course duration is 7-10 days in pneumococcal pathogens or up to 21 days if other bacteria caused the disease.
- Bronchitis: the antibiotic is taken by 500 mg two times a day with an interval of 8 hours or 875 mg every 12 hours. The therapy duration is 7-10 days.
- Otitis media: the treatment course is around 12-14 days. The daily dosage is 250 mg 2 times a day with an interval of 8 hours or 500 mg every 12 hours. In case of severe and complicated infectious process, the dosage can be increased to 500 mg 2 times a day or 875 mg once a day.
- Pyelonephritis (kidney infection): the medication is administered two times a day by 250 mg or 500 mg once a day for 2 weeks.
- Bacterial sinusitis: the medication is taken 2 times a day by 250 mg or by 500 mg once a day for 10 days.
- Skin and soft tissue bacterial infections: the medication is taken 2 times a day by 250 mg or by 500 mg once a day for7 days. If the inflammation is gone within 3 days after the therapy start, the treatment can be discontinued.
- Urinary tract bacterial infection: the medication is taken 2 times a day by 250 mg or by 500 mg once a day for 3-7 days.
The medication is suitable for the treatment of infections in children but the dosage is calculated individually based on the body weight. The medication is administered in form of suspension prepared from the pills and water.
What is the mechanism of action the antibiotic?
Before you buy Amoxicillin and Clavulanate, you may want to know how the medication is different from other antibiotics and how the effect is achieved. This medical guide is designed to be helpful and understandable for people without a medical background so here you can find a simplified explanation.
Amoxicillin violates the synthesis of certain enzymes and proteins necessary for the bacteria growth and replication. The damaged bacteria are unable to grow and replicate and simply dissolve in the body. Subsequently, they are washed out with urine and feces. The antibiotic is effective against the majority of gram positive and negative bacteria and anaerobic bacteria.
By its pharmacological properties, the medication is similar to Ampicillin but has better bioavailability, i.e. a bigger share of the medication is active within the body after the intake. However, the medication is susceptible to the lowering of the effect due to the release of certain substances produced by some of the bacteria. In order to avoid the lowering of the effect, the drug is commonly combined with Clavulanate which protects the active substance of the antibiotic from degradation.
The effect of the drug is observed within 15-30 minutes after the pill intake and is maintained throughout the following 8 hours. The effect of the medication isn’t influenced by food so the pills can be taken with our without food.
Whom Augmentin is contraindicated?
You should not buy Augmentin or another drug with the same composition if you are hypersensitive to the penicillin-group antibiotics, including penicillin, cephalosporins, carbapenems, after the medication intake you develop allergic reactions such as rash. The medication is also contraindicated in asthma, infectious mononucleosis, pollinosis, lymphocytic leukemia, liver failure, history of gastrointestinal diseases and especially colitis associated with the use of any antibiotics, during breastfeeding or in elderly patients.
The drug should be cautiously used during pregnancy, kidney failure, and history of bleeding. In such cases, the drug should be used under a doctor’s supervision.
What are possible adverse reactions of Augmentin use?
Antibiotics are one of the groups of medications that are associated with higher rates of adverse reactions. Therefore, do not be surprised if you have one or several side effects from their use. However, please note that some of them do require medical assistance.
The most common side effects of Augmentin are dysbiosis (irregular stool, diarrhea, and pain in the intestines, flatulence, and so on), candidiasis, indigestion, nausea, vomiting. Other side effects are headache, dizziness, skin rash, redness of the skin, runny nose, pain in the joints, swelling, excitation, anxiety, insomnia, depression, tachycardia (irregular heart beat), and others.
If after you buy Generic Augmentin and start using it you experience some of these side effects, do not blame it on the fact that the medication is a generic and not the brand drug. These side effects are associated with the active substance contained both in the branded and generic drugs. If the side effects are moderate to severe, consult your doctor about how to minimize them. In some cases, the discontinuation of the therapy and selection of another antibiotic are required.
The medication’s effect is primarily influenced by antacids, glucosamine, laxatives, and aminoglycosides. The effect is enhanced by ascorbic acid.
The drug can be used in combination with certain antibiotics for an enhanced effect in the most severe bacterial infections. However, some of the antibiotics suppress the effect of Augmentin.
If you use any medications, vitamins, or supplements during the time you plan to start using Amoxicillin and Clavulanate, consult your doctor first or at least read the complete instruction that accompanies the pills and check that you don’t use any drugs which will harm your body when combined with this antibiotic.
The symptoms of the overdose are nausea, vomiting, and diarrhea. The treatment requires the use of activated carbon or other sorbents within 2 hours after the overdose. In severe cases, hospitalization, gastric lavage, hemodialysis and other procedures performed at the hospital are required.
Where to buy Amoxicillin and Clavulanate?
The medication is sold with Rx only in the U.S. and some other countries. Our pharmacy is located in the country where the drug is sold over-the-counter. We sell both generics and branded drugs at low prices. If you want to save and get the drug without a prescription you can order it from our online pharmacy.
Amoxicillin and Clavulanate shipping by Rxshop
We ship all medications worldwide. To find out more about the cost and time of delivery, please read the corresponding section.
Our doctor prescribes Augmentin online for free, and there is no doctor’s consultation fee.
All orders of Augmentin arrive in discrete unmarked parcels. We leave the shipment description blank.