Generic Pulmicort (Budesonide 100 mcg) guide:
What is the medication marketed as Pulmicort?
Pulmicort is a brand name patented for the medication called Budesonide. The active agent of the medication is a glucocorticoid, i.e. a type of steroid hormone that reduces the inflammation, has anti-allergic, and immunosuppressive effects.
For the first time, the formula of the substance was patented in 1973. In 1981, it was first used for the therapy of asthma. Currently, as the patent of the formula developer expired, the same medication is produced by numerous pharmaceutical companies but is sold under different names.
The medication is available in different forms: as capsules for oral use, ointment for local application, nasal spray, vials for rinsing the nose, suppositories for bowel diseases, and the aerosol inhaler for asthma. On this web page, we offer you to buy Pulmicort in a generic version. Here in this section of our online pharmacy, you can buy anti-asthma medications that are also suitable for obstructive lung disease, chronic bronchitis, and emphysema. If you need Budesonide for other condition, please look for it in other sections or contact our pharmacists for an advice.
The inhaler has a prolonged effect and therefore can be used once daily. It is characterized by local anti-inflammatory action due to high lipophilicity (affinity for organic substances) and ability to penetrate intracellularly, bind to glucocorticoid receptors. The mechanism of action of Budesonide is built on the formation of complexes with the glucocorticoid receptors of the cytoplasm. These complexes made of hormones and receptors then penetrate the nuclei of target cells, bind to DNA and activate genes that are responsible for the production of lipocortin. Lipocortin is an inhibitor of phospholipase A2 - the enzyme, it inhibits the synthesis of mediators of inflammation: histamine, leukotrienes, and cytokines.
Besides, the medication also prevents the migration of inflammatory cells, elevates the number of active beta-adrenergic receptors, and restores the body's response to beta-adrenergic bronchodilators after long-term use.
The drug is rapidly absorbed after inhalation. 34% of the dose is stored in the lungs. Absolute system availability is 39% of the received dose. The maximum concentration of Budesonide in the blood plasma is reached 30 minutes after inhalation. The amount of distribution is approximately 2-3 l per kilogram of the body weight. Metabolism of most of the preparation (about 90%) occurs in the liver with the action of the CYP3A4 enzyme with the production of metabolites with low glucocorticosteroid activity. Nearly 90% of the dose goes into an inactive state already during the first passage through the liver. Metabolism in the lungs is insignificant. In adults, the half-life of the preparation is on average two hours, in children it is one and a half hours. The binding of the prepration to plasma proteins varies from 85 to 90%. The active substance is excreted in the urine (70%) and bile. Since the main action of the preparation occurs in the respiratory tract, there is no data on the relationship between plasma concentration and the potency of its action.
What is the medication sold as Generic Pulmicort?
Generic Pulmicort sold at this web page is identical to the branded medication in a form of aerosol. It is simply made by another pharmaceutical company, a well-known manufacturer Cipla. The generics are ideally all identical to the branded medicines but it is not always so. Only the reliable manufacturers are able to ensure that their products fully correspond to the original formula and effect of the branded drug. We sell only the best quality generics that had been thoroughly tested and approved for international selling.
Generic medications are able to be produced when the exclusive right of the developer for the production of the medication expires. This practice is approved and even promoted by the World Health Organization to ensure that people from all countries and social classes have access to the most effective and innovative medications. The cheaper price of the generic doesn’t indicate its lower quality. In fact, the high price of the branded medicine is unreasonable. Therefore, when you buy Generic Pulmicort you basically obtain the same medication but without overpaying for the advertised name.
When should you buy Budesonide inhaler?
The inhaler is used for the combination therapy of bronchial asthma and chronic obstructive lung disease. It means that if you have a condition for which the medication is prescribed you can buy the inhaler but you must make sure to talk with your physician, respiratory specialist, lung specialist or allergist about what other medications you need to prevent the bronchospasm, stop it when an acute episode occurs, and how to reduce the inflammation. You should know that these conditions aren’t treated with a single medication and require a set of measures to prevent acute suffocation as well as worsening of your bronchi and lungs conditions. Therefore, it is reasonable to buy Budesonide only when your doctor tells you to do so and use it precisely as prescribed along with other medications for your condition.
When must not you buy Generic Pulmicort?
The preparation in a form of inhaler is contraindicated to be used if you are allergic to any component of the medication, in lung tuberculosis infection, and fungal infections of the respiratory tract.
The use in pregnant women is possible only if the anticipated benefit to the mother is bigger than the risk to the unborn baby. Besides, fertile women whom the medication is prescribed must be checked for pregnancy before the start of the therapy with the inhaler and should use reliable contraception for the whole treatment course to avoid pregnancy.
The medication should be cautiously used if you suffer from bacterial or viral infection of the respiratory tract.
What adverse effects development is possible when the inhaler is used?
When you buy Generic Budesonide inhaler and begin to use it, you can develop such adverse reactions as temporary change of the voice, sore throat, dryness or irritation of the mouth or pharynx, cough; candidiasis of the oral mucosa, nausea, pharyngitis, and paradoxical bronchospasm.
In case you suffered a bronchospasm or any other reactions that look like allergy, for instance, skin rash, swelling of the tongue, and so on, you should inform your doctor immediately.
What combinations of medications should you avoid with this inhaler?
Before you order Generic Pulmicort, you need to check with your healthcare provider that you don’t use any medicines that are incompatible with this inhaler.
The metabolism of the inhaler’s active agent is made in the liver with the action of the CYP3A4 enzyme. The inhibitors of this enzyme can increase the level of Budesonide in the blood plasma and the likelihood of adverse reactions development. It is advised to avoid using such medicines together. Consult your doctor whether any medications that you use if you use any fall into this category.
According to the clinical trials, women who received the inhaler along with estrogens or high doses of birth control pills suffered from an elevated level of Pulmicort in the blood plasma and subsequent adverse effects. This negative effect can be avoided in case the contraceptives are used in the lower doses but you must consult your doctor instead of lowering the dosage by yourself as you may need other birth control pills with the different dosage rather than the reduction of the dosage of the pills you currently use.
Overdose of Budesonide inhaler
In long-term use of high doses of the inhaler, you can develop such systemic negative effects as swelling or widening of the face and oppression of the hypothalamic-pituitary-adrenal system. The treatment requires the normalization of the electrolyte balance with the use of diuretics that do not affect potassium, such as spironolactone and triamterene.
How to use Generic Budesonide inhaler?
Children aged from five to twelve years should receive 200-800 micrograms daily split into 2-4 inhalations.
Adults and children older than twelve years should receive 200-1600 micrograms of the medication in two-four inhalations.
After the desired clinical effect is achieved, the daily dosage should be little by little lowered to the minimum dosage that is effective for the control of the symptoms.
After each inhalation of the aerosol, you need to rinse your mouth with water.
When you order Pulmicort from our pharmacy, along with the inhaler you will receive the instruction on how to use it properly. However, we still highly encourage you to consult your healthcare provider on how to use it and what dosages are the best for your case.
Before you use the inhaler, you need to check its expiry date and use it only if it’s still hadn’t reached it. If the inhaler is new or hadn’t been in use for at least a couple of days, you need to shake it well and then spray a dosage in the air to clean up the aerosol hole and make sure that it is working.
Where to buy Pulmicort?
There is a huge difference between the price of the branded medication and a generic version of the inhaler but there is no point of paying more money for the brand name only. To save your money on the therapy, order Budesonide from this web page and we guarantee that you won’t regret your decision!
We deliver all parcels internationally via standard and express mail services. You will receive your parcel wherever you are.
Our doctor prescribes Budesonide online for free, and there is no doctor’s consultation fee.
All orders of Budesonide arrive in discrete unmarked parcels. We leave the shipment description blank.