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More facts about Generic Altace (Ramipril 2.5 mg):
Generic Altace (Ramipril 2.5 mg) guide:
Generic Altace (Ramipril) is a medicine used to lower the blood pressure in people who are diagnosed with hypertension or congestive heart failure. The drug is an angiotensin-converting-enzyme inhibitor that decreases the heart oxygen demand.
When should the drug be used?
You can buy Generic Altace (Ramipril 10 mg) if you are diagnosed with hypertension, congestive heart failure (the drug should be used in a combination therapy) including the one that develops on the 2-9 day after myocardial infarction. The medication is also prescribed for diabetic nephropathy (kidney disease that develops due to diabetes), nephropathy due to chronic diffuse kidney diseases (preclinical and clinical stages), including chronic glomerulonephritis with severe proteinuria.
The medications based on the active substance Ramipril are also a common part of the preventive therapy for lowering the risk of myocardial infarction or sudden cardiac death in the patients with coronary artery disease including those who have had suffered a myocardial infarction, percutaneous transluminal coronary angioplasty or coronary artery bypass graft.
What is the mechanism of action of Generic Altace 5 mg (Ramipril)?
The medication is an angiotensin-converting-enzyme inhibitor that blocks the transformation of angiotensin type one into angiotensin type 2, a substance that narrows the vessels. Due to this, the hypotensive effect is achieved.
In prolonged use, the medication contributes to the reverse development of myocardial hypertrophy in patients with arterial hypertension and reduces the frequency of arrhythmias in myocardial reperfusion; improves the blood supply to the ischemic myocardium; prevents vascular endothelial changes caused by high-cholesterol diet.
The medication also provides cardio protective effect through the impact on the synthesis of prostaglandins, induction of formation of nitric oxide in endotheliocytes. It activates the kinin system, prevents the decay of bradykinin (increases its concentration), and increases the synthesis of prostaglandins. Altace 2,5 mg strengthens coronary and renal blood flow, reduces the aggregation of platelets. Increases the sensitivity of tissues to insulin, the concentration of fibrinogen, stimulates the synthesis of the tissue activator profibrinolysin (plasminogen) promoting thrombolysis.
The blood pressure lowering effect is observed within 1.5 hours after the oral pill intake. The maximum effect is achieved within 5-9 hours. The total effect lasts for 24 hours. The drug doesn’t cause withdrawal syndrome.
Generic Altace (Ramipril) reduces the mortality in the early and distant periods of myocardial infarction, lowers the frequency of repeated heart attacks and the development of heart failure, improves the quality of life for people with congestive heart failure, and slows down the progression of congestive heart failure development in people with pronounced kidney function violation in diabetic nephropathy.
How to use Generic Altace (Ramipril)?
It doesn’t matter whether you buy Generic Altace (Ramipril) or the brand-name drug the dosages are the same because the medications are identical. However, before you start using the medication, make sure to check with your doctor that it is a correct drug for you and the dosage per pill is corresponding to your treatment plan.
The pills should be swallowed without chewing with sufficient amount of water (1/2 of the glass). The medication’s effect isn’t influenced by food, so you can take it before or after meal.
- Hypertension: the initial dosage is 2.5 mg taken once a day. If the effect is insufficient, the dosage can be gradually increased every 2-3 weeks until the desirable effect is achieved. The maximum daily dosage is 10 mg.
- Congestive heart failure: the initial dosage is 1.25 mg a day. If the dosage is insufficient, it can be doubled 1-2 weeks after the therapy start. The maximum daily dosage is 10 mg.
- Congestive heart failure treatment after the infarction: the initial dosage is 5 mg a day divided into two intakes (2.5 mg in the morning and 2.5 mg in the evening). If the dosage is poorly tolerated, it is lowered to 1.25 mg taken two times a day within the first two days of the treatment start. If the increase of the dosage is required, it should be divided into two intakes during the first 3 days of the treatment. Later, the whole dosage can be taken in one intake. The maximum daily dosage is 10 mg.
- Diabetic and non-diabetic nephropathy: the initial dosage is 1.25 mg a day. If the dosage is insufficient, it can be gradually increased every 2-3 weeks until the desirable effect is achieved. The maximum daily dosage is 5 mg.
- Prevention of myocardial infarction, stroke and coronary death: the initial dosage is 2.5 mg a day. If the dosage is insufficient, it can be doubled one week after the therapy start. After three weeks of the treatment, the dosage can be doubled again. The maximum daily dosage is 10 mg. In patients who had previously taken diuretics, the initial dose should be 1.25 mg.
Patients who used diuretics should stop using them 2-3 days before starting the therapy with Ramipril.
For whom the drug is contraindicated?
You should not buy Generic Altace (Ramipril) if you have hypersensitivity to the drug or other angiotensin-converting-enzyme inhibitors, have ever had angioedema, severe renal failure (creatinine clearance less than 20 ml per minute), during pregnancy or if you breastfeed.
The drug should be used with caution in severe damage of coronary and cerebral arteries, systemic disorders of connective tissue, malignant hypertension, bilateral stenosis of the renal arteries, stenosis of the artery of a single kidney, after kidney transplantation, and in other conditions.
If you are not sure whether the drug is safe in the condition that you have, you should inform your doctor about it and other conditions that you have or ever had before using the drug.
What side effects can Altace (Ramipril) cause?
The drug can cause a sharp decrease in blood pressure, orthostatic hypotension, myocardial or brain ischemia, myocardial infarction, arrhythmias, syncope, ischemic stroke, tachycardia, peripheral edema, increase in the amount of excreted urine, decreased potency, erectile dysfunction, headaches, general weakness, insomnia, nausea, vomiting, diarrhea or constipation, pancreatitis, cholestatic jaundice, digestive disorders, and others.
If after the intake of Altace or Generic Altace pill you experience any of these or other side effects, inform your doctor about them so he or she would advise you dosage adjustment or measures to cope with the negative effects.
What medications Altace (Ramipril) should not be combined with?
The drug enhances the hypoglycemic effect of sulfonylurea derivatives and insulin, increases the risk of leukopenia development in simultaneous use with allopurinol, cytostatics, immunosuppressants, procainamide.
When combined with hypotensive drugs, diuretics, narcotic analgesics, drugs for general anesthesia, sleeping pills, and ethanol the hypotensive effect (blood lowering effect) is increased.
When combined with potassium-sparing diuretics the risk of hyperkalemia development increases.
With lithium-containing drugs, the concentration of the latter is the blood increases.
Nonsteroidal anti-inflammatory drugs and salt can reduce the blood lowering effect of the medication.
There are other medications with which Altace (Ramipril) can cause a variety of negative effects to the body. Therefore, before starting the treatment, make sure to consult your doctor about the drugs you already use or plan to use along with the hypotensive medication.
What should you do in the overdose with Altace (Ramipril)?
The overdose can cause acute arterial hypotension, violation of cerebral circulation, angioedema, myocardial infarction, and thromboembolic complications.
Treatment of the overdose’s consequences includes the reduction of the dosage or complete withdrawal of the drug; gastric lavage, measures to increase volume of circulating blood (infusion of isotonic sodium chloride solution, transfusion of other blood-substituting fluids). Also, symptomatic therapy is needed such as administration of epinephrine, hydrocortisone, and antihistamines.
Where to buy Altace (Ramipril)?
You can buy Altace (Ramipril) at your local drugstores if you have a prescription. If you have an expired prescription or simply want to get the medicine cheaper, you can order it from our online drugstore. We sell both the brand medication and its generic version. Even paying for the shipping you can significantly save as we sell the drug cheaper than the U.S. pharmacies. Besides, we won’t ask you for a prescription because our pharmacy is located in the country where Altace (Ramipril) is an over-the-counter drug.
Brand and Generic Altace (Ramipril) shipping by Rxshop
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