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More facts about Generic Pravachol (Pravastatin 10 mg):
Generic Pravachol (Pravastatin 10 mg) guide:
What are Pravachol pills?
Pravachol is an advertised name owned by a Japanese pharmaceutical company who first developed the active substance Pravastatin. The medication is currently also manufactured by other pharmaceutical companies but under other, less known names.
Pravastatin is a semi-synthetic hypolipidemic agent, belonging to the group of statins for oral administration. It was discovered as a component of a certain fungus and later synthesized artificially to have the substance in larger amounts and with lower toxicity than the natural substance.
The medication represents the new class of lipid-lowering drugs - competitive inhibitors of HMG-CoA reductase that inhibit the biosynthesis of cholesterol. The effect of the medication is due to two mechanisms. First of all, it causes the moderate decrease of intracellular cholesterol pools due to the reversible suppression of the activity of HMG-CoA reductase. It provokes the increase of the number of receptors for lipoproteins of low density on the surface of cells and the increase of catabolism (decomposition into simpler substances) and excretion from the body of low-density lipoproteins (“bad” cholesterol). Secondly, the medication suppresses the formation of low-density lipoproteins through the suppression of the synthesis of lipoproteins of very low density (predecessors of the low-density lipoproteins) in the liver.
Pravachol or Pravastatin causes the overall lowering of total cholesterol, the lowering of low-density cholesterol, apolipoprotein B, and also triglycerides. At the same time, it contributes to the increase of the cholesterol content of high-density (HDL) and apolipoprotein A.
The therapeutic effect of the medication use is noticed within a week after the start of the pills intake. The maximum effect can be usually assessed within four weeks of intake.
The single daily intake in the evening has the same efficacy as the same dosage split into two intakes as the major amount of “bad” cholesterol is produced at night.
The medication is quickly absorbed but only 34% are active within the body. The maximum concentration of the active substance in the blood plasma is achieved within an hour or an hour and a half after the pill intake. The effect of the medication isn’t reduced by the food or intake on the empty stomach unlike the effect of other similar medications.
Please note that it is reasonable to buy Pravachol to lower the amount of “unhealthy” cholesterol only if you have followed a special diet and exercised as your doctor prescribed for sufficient amount of time and it didn’t help. The medication is an addition to the healthy lifestyle changes that are the main remedies for the increase of cholesterol.
What is Generic Pravachol? How is it different from the branded medicine?
As we have already mentioned, the active substance of the branded medication was developed by a certain pharmaceutical company who registered a trade name Pravachol for it. Although the same name for the medication cannot be used by other manufacturers, the exclusive right to use the formula for Pravastatin creation had already expired. It means that other drug-making companies can make the same preparations without violating the copyright of the inventor. It is made so to make all the modern medications available everywhere in the world and at affordable prices.
You probably know that there is a huge price difference between the generics and branded medicines. Not everyone can afford branded medications so this policy of generics making was introduced. It was initially aimed to help people from the developing countries since all new medicines are invented in the developed countries where the average incomes and respectively the prices are higher. However, many brand drug-makers price their products so high that even the people from the developed countries cannot afford them if government or insurance do not cover the part of the cost. This is the reason more and more people buy Generic Pravachol and other generics instead of the branded medicines.
Do not worry about the quality and effect of generic. It is different from the branded medication only by the name and the price. No medication would be allowed into the market if it didn’t correspond to the claimed formula.
When is Generic Pravachol used?
The preparation is appointed for the therapy of hyperlipidemia (high content of lipids in the blood) without ischemic heart disease for the reduction of the risk of myocardial infarction; atherosclerosis and ischemic heart disease, including myocardial infarction to slow the progression of atherosclerosis and reduce the likelihood of recurrent myocardial infarction; type II hyperlipidemia (increased low-density lipoprotein, very low-density lipoprotein, and total cholesterol), familial hypercholesterolemia (in patients with transplanted heart to reduce the likelihood of developing coronary angiopathy).
Please note that even if you have any of these conditions it doesn’t necessarily mean that you need to buy Pravastatin. First of all, medicines to lower the level of cholesterol are prescribed only after a special low-fat diet and exercise failed to lower the lipids in your blood to the acceptable levels. Secondly, there are plenty of medicines with similar effects that slightly differ so if you believe that you need a medication to lower your level of cholesterol, you need to need to consult your doctor as only he would be able to choose the right medication for you based on your health history.
When the medication cannot be used?
Even if you have the conditions in which the medication is appointed, you may still not be able to enjoy its effect if it is contraindicated for you. For instance, you should not use it while you are pregnant, breastfeeding, if you have hypersensitivity to the medication’s components or any liver disease and/or disruption of its functions.
The medication also cannot be used in children and adolescents. In childhood, Pravastatin is allowed for use exclusively in the case of familial hypercholesterolemia in children older than 8 years. If your child needs the lowering of cholesterol, please consult a pediatrician on what medication you should purchase and then look for it in our range of cholesterol-lowering medicines.
Possible adverse effects of Pravastatin
If you buy Generic Pravastatin for the first time, you can develop certain negative reactions to the medication. For instance, you can start suffering from headache, dizziness, sleep violations, insomnia, vision impairment, nausea, vomiting, diarrhea, loss of appetite, heartburn, bloating, pancreatitis, skin rash, arthralgia, muscle cramps, myalgia, muscle weakness, very rarely rhabdomyolysis (associated with acute kidney failure), myopathy, myositis, polymyositis, and others.
Inform your physician or cardiologist if you have any unpleasant unusual symptoms since you started taking the pills.
Simultaneous use of Pravastatin with other substances
The medication amplifies the effect of indirect anticoagulants. Macrolides, nicotinic acid, immunosuppressants, and other lipid-lowering drugs increase the risk of rhabdomyolysis with acute renal failure (combined use is not recommended).
When combined with cyclosporine, fibrates or erythromycin, the risk of myopathy increases.
If you currently take any medicines or supplements or plan to start taking them while using Pravastatin-based medication, make sure to combine them with the drug only if your doctor approves.
How Generic Pravachol should be used?
Before starting treatment with Pravastatin it is necessary to exclude additional causes of hypercholesterolemia and prescribe a standard diet with a low-fat content for the entire period of therapy.
The drug is taken orally 1 time per day, preferably in the evening, regardless of food intake.
For hypercholesterolemia treatment, the recommended doses are 10-40 mg once a day. The therapeutic effect is observed within a week and the maximum after 4 weeks. Therefore, the analysis of lipids levels should be made periodically and the dose should be adjusted accordingly. The maximum daily dose is 40 mg.
Dosage after heart transplantation for patients taking immunosuppressive drugs is 20 mg of Pravastatin per day. Depending on the effectiveness of treatment with lipid indices, the dose can be brought up to 40 mg under the strict supervision of a doctor.
If you want to order Pravachol for the use in children, make sure to follow the recommendations of pediatrician strictly. The children aged from eight to eighteen years with heterozygous hereditary hypercholesterolemia can take the medication but in different dosages. Children aged from 8 to 13 years are advised to take 10 - 20 mg once a day for (because doses above 20 mg for this category of patients have not been studied). Children from 14 to 18 years are usually appointed from 10 to 40 mg per day for.
Patients of advanced age are not required to adjust the dose if there are no risk factors.
In hepatic/kidney failure the recommendations are the following:
For patients with moderate or severe liver/kidney damage, an initial dose of 10 mg per day is recommended. The dose should be adjusted based on lipid parameters under the supervision of a doctor.
Where to buy Pravachol?
As any other medication, you can get this drug from a regular drugstore but since you are visiting this web page it means that you already know that if you order Generic Pravachol online you can save a lot of money.
Our medstore ships internationally via standard and express mail.
Our doctor prescribes Pravastatin online for free, and there is no doctor’s consultation fee.
All orders of Pravastatin arrive in discrete unmarked parcels. We leave the shipment description blank.