Mevacor (Lovastatin 10 mg)
More facts about Generic Mevacor (Lovastatin 10 mg):
Generic Mevacor (Lovastatin 10 mg) guide:
What is the medication marketed as Mevacor?
Mevacor is not an exclusive medication. It is simply a promoted trade name for the medication called Lovastatin that had been developed in the 1970s. The active substance Lovastatin is actually partially a natural substance found in a type oyster mushroom. When its cholesterol-lowering properties were discovered, the researchers started to work on the synthesizing of the medication and testing of its safety when used by people. After many years of research, the optimal formula was developed and the medication was first approved in 1982. Nowadays, the patent of the inventor had already expired which made it possible for other medication manufacturing companies to make the same drugs and market them but under different names.
Lovastatin is a hypolipidemic medication, i.e. it disrupts the early stages of the synthesis of cholesterol in the liver (in the stage of mevalonic acid). In the body, it forms a free beta-hydroxy acid, which competitively suppresses HMG-CoA reductase and breaks its transformation into mevalonate, as a result of which the synthesis of cholesterol decreases, its catabolism increases. The preparation reduces the concentration of low density and very low-density lipoproteins in the blood and moderately increases high-density cholesterol levels. Besides, it significantly reduces the amount of apoprotein B (included in the composition of low-density lipoprotein) and other circulating components of low-density cholesterol. The expressed therapeutic effect is manifested within 2 weeks, and the maximum effect can be observed within 4-6 weeks from the start of treatment.
When taken orally, the medication is slowly and incompletely absorbed from the digestive (about 30% of the dose taken). The intake on an empty stomach reduces absorption by 30%. The maximum concentration is reached after 2 hours, but then the level in the plasma rapidly decreases and after 24 hours it is 10% of the maximum. Both Lovastatin and its beta-hydroxy-acid metabolite in the common vascular bed circulate in plasma-related form (about 95%).
The stable equilibrium concentration of Lovastatin (and its active derivatives) when applied once a day at night (cholesterol is synthesized mainly at night) is achieved on the 2-3rd day of therapy and 1.5 times higher than due to a single dose. It penetrates the GEB and the placental barrier, accumulates in the liver, where it is oxidized to metabolites, some of which remain active. The preparation, in general, excreted in bile. About 85% of the dose is excreted in feces and only 10% with urine. The pronounced lipid-lowering effect develops in 2 weeks, the maximum - within 4-6 weeks.
You should buy Mevacor or a generic drug with the same composition if diet and exercising failed to lower the level of bad cholesterol in your body.
What is Generic Mevacor? Is its effect different from the branded medication’s effect?
The generic version of the medication, ideally, should be absolutely identical to the branded medication. However, it is not always so. To be sure that you get the right medication, first of all, you should buy Generic Mevacor from a reliable seller. For instance, our online pharmacy specializes in the selling of the best quality generics that are made by reputable generics makers whose medications are properly tested and certified before they are allowed onto the market. Secondly, when you get the generic version of the medication you should check the active substance that should correspond to the active substance of the branded medicine you are prescribed to take. In case of Mevacor, it must be Lovastatin. Basically, if you get the qualitative generic medication, there are only two things that differentiate it from the branded medicine – the name on the box of pills and the price per pill. The different name is due to the fact that other producers cannot use the copyrighted name but they can use the formula. The cheaper price is due to the lack of research, i.e. generic drug makers do not develop the medicines themselves. Besides, all branded medicines, especially marketed in the U.S., are highly overpriced. The generics make it possible for people from all social classes and those without insurance to receive the best, modern and effective treatment without going broke. The idea of their creation is to balance the chances for effective and modern treatment for all people regardless of their incomes. This policy was initially aimed at helping people from the developing countries but considering the high prices for the branded medicines, more and more people from the developed world also prefer generics these days.
When should I buy Mevacor?
It is recommended to start using the pills only after other measures such as diet, exercise, and weight loss have not improved the cholesterol level sufficiently. The medication is appointed for the following conditions: primary hypercholesterolemia with a high concentration of low-density lipoprotein type IIa and IIb (with ineffective diet therapy in patients at increased risk of coronary atherosclerosis), combined hypercholesterolemia and hypertriglyceridemia, lipid profile correction in patients with uncomplicated type 1 and 2 diabetes mellitus, hyperlipoproteinemia (not amenable to special diet and physical activity), and atherosclerosis.
Please do not buy Lovastatin before consulting your doctor even if you have any of the above-listed conditions. It is important for a specialist to assess your general condition taking into account other factors before choosing a medication for you.
When shouldn’t I buy Generic Mevacor?
The prohibitions for the medication use include hypersensitivity to the pills’ components, acute liver diseases, pregnancy and lactation, liver dysfunction, and the general bad condition of a patient. Besides, it must not be used in children.
If you buy Generic Lovastatin and suffer from the following conditions, you must use the medication cautiously and in case of any adverse effects discontinue the therapy: liver diseases (including in the past), alcoholism, organ transplantation, concomitant immunosuppressive therapy, chronic renal failure, and urgent surgical manipulations (including dental procedures).
Side effects Generic Lovastatin can cause
Generally, the drug is well tolerated. Adverse reactions, if they occur, usually proceed in a mild form and are short-lived. The possible side effects caused by the generic are the same as the negative effects caused by the branded drug. They include nausea, vomiting, loss of appetite, abdominal pain, constipation, diarrhea, indigestion, flatulence, dry mouth, taste change, sour regurgitation, pancreatitis, hepatitis, cholestatic jaundice, dizziness, headache, agitation, anxiety, depression, cognitive disorders, diabetes, and others.
If you start suffering from any malaise taking the pills, make sure to inform your doctor right away.
Concurrent use with other substances
When you order Mevacor, make sure to talk to your doctor about the possibility of use of other medicines along with this drug as they can negatively interact.
For instance, the medication enhances the anticoagulant effect of indirect anticoagulants and increases the risk of bleeding.
The risk of rhabdomyolysis and acute renal failure is very high in the concurrent use of Generic Mevacor with immunosuppressants, Gemfibrozil, nicotinic acid, cyclosporins, and erythromycins. Cyclosporin increases the plasma concentration of Lovastatin metabolites. Fibrates, nicotinic acid, itraconazole and other antifungal drugs of the azole group, and erythromycin increase the risk of myopathy.
Cholestyramine and colestipol reduce the bioavailability of the medication. Therefore, Lovastatin should be used not sooner than 4 hours after the administration of these drugs.
Dosages of Generic Mevacor
If when you order Generic Mevacor pills you have the recommendations of your doctor on how to use the pills, follow them without any changes even if another name is indicated on the box of pills while the name of the active substance is Lovastatin.
Before the start of the therapy and during the therapy, you should follow a low cholesterol diet. Usually, in mild forms of hypercholesterolemia, the medication is taken orally once a day in the evening with meals in a dose of 20 mg. The recommended dosages are in a range of 10-80 mg a day. If a patient needs to lower the level of low-density lipoproteins by 20%, the treatment can be started with 20 mg a day at once. In the insufficient effect, the dosage can be increased with intervals of four weeks to 40 or even 80 mg a day taken once a day or split into two intakes.
The maximum daily dosage is 80 mg split into two intakes, i.e. one during the breakfast and the second one during the dinner. During treatment, it is recommended to periodically check the blood cholesterol level for possible dose adjustment.
The duration of treatment depends on the manifestations and severity of the course of the disease.
Children aged 10-17 years (girls are prescribed only in the presence of menstruation for at least 1 year) with family heterozygous hyperlipidemia are recommended to be administered 20 mg per day. The maximum daily dose should not exceed 40 mg.
Overdose symptoms and treatment
typical symptoms of an overdose of the medication are the weakness of facial muscles, general muscle weakness, impaired liver function, nausea, vomiting, and diarrhea.
Treatment required is symptomatic. There is no specific antidote and hemodialysis is ineffective.
Before you order Lovastatin, you should know that the prolonged use of the drug increases the likelihood of side effects.
If you notice the pain in the muscles or weakness, especially against the background of fever, it is necessary to stop taking the drug.
Before the therapy start and during it, you should do blood tests to check liver function. You should consult your doctor about in what symptoms you must stop using the medication immediately. For instance, the symptoms that indicate the liver dysfunction caused by the medication include including fatigue, lack of appetite, pain in the right side of the abdomen, dark urine or jaundice (yellowing of the skin).
Where to buy Mevacor cheap?
If you want to save on the visits to your doctor and the pills, you should without any doubts order Generic Lovastatin from our online pharmacy. It is the same medication as the branded drug simply made by another company and sold cheaper because of its less advertised name.
Mevacor shipping terms
We offer you standard and express shipping to any corner of the world. Make sure to choose the right delivery method to get your pills right on time.
Our doctor prescribes Lovastatin online for free, and there is no doctor’s consultation fee.
All orders of Lovastatin arrive in discrete unmarked parcels. We leave the shipment description blank.