Generic Prandin (Repaglinide 0.5 mg) guide:
What is the preparation marketed as Prandin?
The name Prandin is mostly known in the U.S. and a few other countries while internationally the medication is known as known as Repaglinide. It is the name of the active substance which is indicated on the packages with pills under all trade names of the medication. Yes, the same Prandin is available under a variety of other names because it was developed in 1983 and currently not only its inventor but all other pharmaceutical companies have access to the formula.
Repaglinide is a fast-acting oral stimulant of insulin secretion. It rapidly reduces blood glucose levels, stimulating insulin secretion by the pancreas, and the effect of the medication depends on the number of functioning b cells remaining in the islets of the gland.
Repaglinide covers ATP-dependent potassium channels in the membrane of the b cells with a special protein. This causes depolarization of the b-cells and leads to the opening of calcium channels, increases the entry into the cell of calcium ions, which stimulate the secretion of insulin.
In patients with type 2 diabetes, an increase in the concentration of insulin in the blood occurs within 30 minutes after ingestion of Repaglinide. This lowers blood glucose levels during the entire period of digestion of the food taken.
The concentration of the medication in blood plasma is rapidly decreasing, its low level is observed in patients with type II diabetes within 4 hours after its administration. After taking 0.5 to 4 mg of Repaglinide, patients with type II diabetes showed a dose-dependent decrease in glucose concentration. Based on the results of clinical studies, it is recommended to take Repaglinide before meals. The drug is usually taken 15 minutes before meals, but the time of admission can vary: the drug can be taken immediately before meals or 15-30 minutes before eating.
Your doctor can prescribe you to buy Prandin only if you have already tried a curative diet and exercises to cope with the elevated blood sugar and it didn’t work. It is essential to undertake all measures to lower the sugar level without medications first and continue them while taking the pills in order to help your body itself participate in the regulation of glucose metabolism.
Can you buy Generic Prandin when you are appointed the branded medication?
It is absolutely normal to purchase the generic version of the medication to save your money on the long-term treatment as the certified and reputable generics provide the same effect as the branded medication. But in order to be sure that you acquire the qualitative medication, you have, first of all, check the reputation of the seller if you opt for an online pharmacy. Then, you need to verify that the active substance corresponds to the one used in the branded medication which in case of this medication must be Repaglinide. Next, make sure to order the tablets with the dosage appointed to you. For instance, at our online pharmacy, you can buy Generic Prandin with the dosage of 0.5 mg, 1 mg, and 2 mg. If your healthcare provider prescribes you 0.5 mg, do not order the higher dosage as you would need to split the tablet manually and can easily get the wrong dosage. Moreover, some formulations lose a share of its effectiveness when crushed.
As for the lower price of generic, do not worry, it doesn’t mean that the medication is of poorer quality. It is due to the fact that the generics makers didn’t invent the medication themselves, they also do not spend money on the promotion of their medications as do the branded drug makers. Generics are made using absolutely identical chemical formula and ingredients and their price reflect the real production cost of the tablets.
When can you buy Prandin? What are indications for the tablets use?
The medication is appointed for the therapy of diabetes type II, but do not hurry to buy Repaglinide if you had been diagnosed with the condition, as this medication is used only if certain terms are met.
The preparation can be prescribed for the blood sugar lowering in diabetes type II alone combined only with physical exercises and a curative diet aimed to lower the body mass of a patient if they solely do not provide this effect.
The preparation can be also prescribed to be taken along with Metformin or Thiazolidinedione for the therapy of diabetes type II if the sufficient blood sugar lowering effect cannot be achieved by the use of these medications separately.
Please note that the treatment with any medications is appointed only after a special diet and appointed physical exercise regimen followed for a sufficient amount of time hadn’t provided the sufficient results according to your doctor.
When should not you buy Generic Prandin?
The medication is contraindicated in hypersensitivity to the components of the pills, in diabetes type I (insulin-dependent diabetes), C-peptide-negative diabetes, diabetic ketoacidosis with the presence or absence of a pre-comatose condition, severe liver or kidney dysfunction, and during the therapy with Gemfibrozil, conditions that require the use of insulin such as severe infectious diseases, major surgical interventions, pregnancy, and breastfeeding.
It is highly not advised to use the medication also in people who hadn’t reached eighteen years of age and people older than 75 years of age as safety and efficacy in patients of these age categories are not defined.
The preparation should be discreetly used in people suffering from chronic alcoholism, fever syndrome, chronic renal failure.
If you suffer from any of these conditions or fall into the restrictive age category, make sure to inform your healthcare provider about it before you buy Generic Repaglinide.
How to take Generic Repaglinide?
You don’t have to change the prescribed dosages if you have a prescription from your doctor if you purchase a generic version of the medication as they are the same drugs. If you don’t have guidelines from your healthcare provider, you can get the information from this article as we took it from the official instruction but we still highly encourage you to ask your doctor for individual recommendations.
The tablets are taken orally without chewing before the main meals of the day. The dosages are selected individually based on the sugar level in blood and urine checked by the patient at home and blood sugar tests made by a doctor. These tests must be done frequently in order to detect the minimum effective dosage of the medication for prolonged use. They are also needed to detect the inadequate, i.e. below the norm lowering of the blood sugar at the beginning or during the therapy.
The selected by a doctor dosage is usually taken 15-30 minutes before a meal. However, if in a particular patient it starts acting sooner, the pills can be taken right before a meal. If you skip the meal or have an additional full meal, you need to skip the dose (in the first case) or add the dosage (in the second case, for instance, if you are at a festive table).
The starting dosage is chosen based on the reaction of a patient to the minimum dosage of 0.5 mg before each meal intake. After one-two weeks (your doctor can tell you to do this sooner or later based on your condition severity), the effect is assessed by a doctor and the dosage is adjusted respectively, i.e. either risen, lowered, or left the same. Patients who have ever used any other antidiabetic medications can start the therapy with 1 mg taken before meals.
The maximum admissible dosage is 4 mg before a meal. The maximum daily dosage must not exceed 16 milligrams.
People who are transferred from other antidiabetic oral medications can start the therapy without any adjustments from 1 milligram of Repaglinide taken before a meal. The exact relationship between doses of Repaglinide and other oral hypoglycemic agents has not been established but this is a standard recommendation suitable in most cases.
If you use Metformin or Repaglinide only, you can order Prandin and use these medications together. The starting dosage of Generic Prandin in this combined therapy is the same as in the single-drug therapy, i.e. 0.5 mg before each meal.
What adverse reactions can Generic Prandin provoke?
The most frequent adverse effects associated with the medication use are related to the changes of the glucose level in the blood, i.e. hyperglycemia (high blood sugar in insufficiency of the medication) or hypoglycemia (low blood sugar if the dosage is bigger than suitable).
The frequency of adverse effects occurrence depends on the specifics of the treatment and individual features of a patient, i.e. eating habits, dosages, physical exercises, stress, and so on.
Other possible negative reactions to the medication are nausea, pain in the stomach, allergic reactions, liver function impairment, vision violation, and others.
Before you order Generic Prandin and start taking the tablets, your doctor needs to instruct you about which adverse reactions are the most dangerous and you should inform him or her about.
What interactions with other substances should you avoid?
The effect of the medication is enhanced, i.e. the blood sugar is lowered even more, if you take along Generic Prandin the medications from the class of beta blockers, inhibitors of angiotensin-converting enzyme, chloramphenicol, indirect anticoagulants, NSAIDs (nonsteroidal anti-inflammatory drugs), probenecid, salicylates, MAO inhibitors, sulfonamides, and anabolic steroids. Alcohol can also contribute to the uncontrollable sugar lowering.
The effect of the medication is lowered with the concurrent use of calcium channel blockers, corticosteroids, diuretics, isoniazid, the nicotinic acid in high doses, estrogens, incl. in the composition of oral contraceptives, phenothiazines, phenytoin, sympathomimetics, and thyroid hormones.
Overdose detection and treatment
If you took a significantly higher dosage of the medication than you should have, you can start suffering from hypoglycemia, i.e. lowered blood sugar. The symptoms are hunger, weakness and tiredness, headache, excitability, anxiety, sleepiness, restless sleep, confusion, nausea, rapid heartbeat, and others. The most severe manifestations are seizures and coma.
Mild to moderate hypoglycemia without the neurological symptoms and loss of consciousness is treated with the intake of fast-digested carbohydrates such as sugar or glucose solution. Later, the adjustment of the dosage or diet should be made.
In severe manifestations, such as seizures, headache, rapid heart rate, you need to seek emergency help as soon as you started developing the symptoms as they require the treatment at the hospital or you can fall into a coma.
Where to buy Prandin?
The cheapest way to get the qualitative medication identical to the branded one is to order Repaglinide from our online pharmacy. We offer only the best generic medication at the most adequate prices and without prescription.
You can order express or standard shipping to your doorstep. We ship internationally so the only difference is the time you have to wait for your parcel to arrive.
Our doctor prescribes Repaglinide online for free, and there is no doctor’s consultation fee.
All orders of Repaglinide arrive in discrete unmarked parcels. We leave the shipment description blank.