More facts about Generic Esidrix (Hydrochlorothiazide 25 mg):
Generic Esidrix (Hydrochlorothiazide 25 mg) guide:
What do you actually get when you buy Esidrix?
Esidrix is a trademark owned by the pharmaceutical company Novartis. The same name cannot be used by other companies. Nevertheless, the same medication is manufactured also by other companies. The active ingredient of this medication is Hydrochlorothiazide. The active agent was discovered in the mid-fifties of the twentieth century and is currently made by a variety of different drug makers because the know-how of the inventors allowing them to make the medication exclusively had already expired. The medication is included in the class of diuretic with moderate activity, in a subgroup of simple thiazide diuretics. These medications are used for hypertension, swelling caused by various reasons, to lower the intraocular pressure in glaucoma, and in other conditions. If your physician prescribes you to buy Esidrix, you can without any doubts look for other medicines with the less known names based on Hydrochlorothiazide which are cheaper but render the same effect.
The effect of the medication is due to the reduction of the reuptake of sodium ions at the level of the cortical segment of the Henle's loop, without affecting the site, itpasses in the medulla of the kidney. Hydrochlorothiazide blocks the carbonic anhydrase in the proximal part of the convoluted tubules, accelerates the excretion of potassium ions, hydrocarbonates, and phosphates in the urine. It virtually does not affect the state of acid-base balance (sodium ions are withdrawn either together with ions of chlorine or bicarbonate ions, so in alkalosis, the excretion of hydrocarbons is increased, in acidosis - chlorides). Hydrochlorothiazide enhances the washing out of magnesium ions but delays the excretion of urates. Hydrochlorothiazide diminishes the washing out of calcium in the urine, reducing the formation of calcium kidney stones.
The preparation has an antihypertensive effect. This action occurs in three-four days, but it may take up to four weeks to achieve the optimal therapeutic effect. The hypotensive effect lasts for a week after the medication use is discontinued.
The action of Hydrochlorothiazide decreases in a decrease in the glomerular filtration rate and stops at a creatinine clearance less than 30 ml per minute.
After taking hydrochlorothiazide, it quickly, but not completely (around 60-80%) is absorbed from the stomach. The urination enhancing effect develops in one to two hours and reaches a maximum after four hours. The total effect lasts for 10-12 hours. Binding to plasma proteins is forty percent. Hydrochlorothiazide penetrates the placenta and into breast milk.
Hydrochlorothiazide is not subject to significant metabolism. The primary way of elimination is renal excretion in unchanged form. Half-life in people with healthy renal function is about six hours, in people with moderate renal insufficiency, it is around eleven hours.
Can you replace the branded medication with Generic Esidrix in the prescribed therapy?
You can buy Generic Esidrix without any hesitation and doubts to replace the branded medication as they are identical medications simply made by different companies. Although Generic Esidrix is not an official name of the medication, i.e. it is not registered; it can be used to find the cheaper analogs of the branded medication because all pharmacists and doctors understand the meaning of the branded name plus the word “generic”.
There are several moments that you need to pay attention to when opt for a generic medication. First of all, you need to buy it either at a regular drugstore or an online pharmacy with a good reputation. Secondly, to be sure that you get the right medication, you have to check that its active substance is Hydrochlorothiazide. Thirdly, since the medication can come in different dosages, it is important to choose the correct dose of the active substance per pill that corresponds to the recommendations of your healthcare provider.
When can you buy Hydrochlorothiazide?
The diuretic is used to reduce swelling caused by various reasons, for instance, congestive heart failure, liver cirrhosis, nephrotic syndrome, renal failure, premenstrual syndrome, liquid retention in excessive body mass, and also caused by medications use, for example, corticosteroids.
Besides, you can also buy Hydrochlorothiazide to lower the blood pressure if your doctor believes that this drug would be suitable for the monotherapy or added to the therapy with other arterial pressure-lowering medications.
The medications based on Hydrochlorothiazide are also appointed for the symptomatic treatment of neurogenic diabetes insipidus (to diminish polyuria), subcompensated forms of glaucoma, and prevention of calcium renal calculus formation.
When shouldn’t you buy Esidrix and its generics?
The medication must not be used in increased sensibility to the main active substance of the medication, other sulfonamides or to any component of the preparation. Besides, it should not be used in severe kidney insufficiency when the creatinine clearance is less than 30 milliliters per minute, mechanical obstruction of the urinary tract, severe hepatic insufficiency, hepatic encephalopathy, anuria, gout, hypovolemia, decompensated diabetes mellitus, Addison's disease, in violation of water-salt metabolism (hypokalemia, hypercalcemia, etc.), during breastfeeding, and in age below 3 years.
The medication is not advised to be used in ischemic heart disease, simultaneous reception of cardiac glycosides, impaired liver and kidney function, pregnancy, and old age.
What medications must you not use along with Generic Esidrix?
You should avoid using the diuretic with Lithium as the kidney excretion of Lithium is lowered in this case and its toxicity is increased.
When you buy Generic Hydrochlorothiazide to use it with other medicines that lower the blood pressure, you should know that they potentiate the effects of each other and you may need the dosage adjustment made by a doctor.
You should cautiously use the medication with cardiac glycosides as hypokalemia and hypomagnesemia, associated with the action of thiazide diuretics, may amplify the toxicity of digitalis.
The concurrent use with amiodarone is fraught with an heightened risk of arrhythmia induced by low potassium level caused by thiazide diuretics.
The effectiveness of oral hypoglycemic agents can be diminished by the use of diuretic and the risk of hyperglycemia can occur.
When combined with corticosteroids and calcitonin an elevation of the washing out of potassium is observed.
Nonsteroidal anti-inflammatory medications can lower the arterial pressure lowering effect of the medication.
The effect of nondepolarizing muscle relaxants when they are combined with Esidrix can be enhanced.
The increased Amantadine toxicity can be noted in the concurrent use with the diuretic.
Cholestyramine diminishes the bioavailability of Hydrochlorothiazide.
The risk of onset of orthostatic hypotension is increased with the intake of ethanol, barbiturates, and narcotic analgesics with the diuretic.
Thiazides can reduce plasma iodine levels associated with proteins.
Before performing parathyroid function tests, the use of thiazide diuretics should be discontinued.
What are adverse effects caused by Esidrix?
You order Esidrix and start taking the pills you may develop the following adverse reactions: electrolyte imbalance, hypokalemia, hypercalcemia, dryness in the mouth, thirst, fast or slow heartbeat, mood swings, cramps and ache in the muscles, nausea, vomiting, tiredness or weakness, hepatic encephalopathy or even coma, slowing down in thinking process, diminished glucose tolerance followed up with diabetes onset, cholecystitis, pancreatitis, stool disturbances, loss of appetite, orthostatic hypotension, thrombocytopenia, hemolytic anemia, vertigo, blurred vision, headache, paresthesia, urticaria, purpura, photosensitivity, anaphylactic reactions, and others.
If you feel unwell after you started the therapy with the medication, inform your doctor right away as some side effects require the immediate discontinuation of the therapy to avoid doing any harm to the body.
The symptoms are dehydration, pronounced electrolyte disturbances, confusion, dryness of the mouth, lethargy, muscle weakness, sleepiness, tachycardia, hypotension, and shock.
The treatment requires the induction of vomiting, gastric lavage, and symptomatic therapy.
How to use the tablets of this diuretic?
The doses must be selected individually whether you buy the branded medication or order Generic Esidrix. Here you can find the regular recommendations but make sure to discuss the dosage regimen with your doctor.
To reduce swelling, the daily dosage is from 25 to 75 mg taken once a day or once in two days. The maximum advisable daily dosage is 100 mg.
To lower the arterial pressure, the recommended dosage is 25-50 mg in a single intake as a single-drug therapy or in combination with other hypotensive medications. In some cases, the doses of 12.5 mg a day are effective. If necessary, the dosage can be subsequently increased but not over 100 mg a day.
In swelling associated with the premenstrual syndrome, the dosage is 25 mg a day. It should be taken when the symptoms start to manifest and till the start of menstruation.
For the therapy of neurogenic diabetes insipidus, the average therapeutic dosage is 50 mg a day. If necessary, the dose can be raised to 100 mg a day.
To lower the intraocular pressure in glaucoma, the daily dosage is 25 mg taken once in one to six days. The effect usually occurs within 24-48 hours.
To prevent the formation of calculi (stones) the regularly appointed dosage is 50 mg 2 times a day.
The daily dosage for children older than three years is 1-2 mg per kilogram of the body mass. Depending on the body weight, children from three to twelve years are administered from 37.5 to 100 mg a day. The dosage can be split into two intakes.
When you are prescribed a long-term therapy, you should know that when you order Hydrochlorothiazide, it is important to check the clinical symptoms of water electrolytes imbalance. It is especially important to do so in people with the high risk, for instance, people with cardiovascular diseases and dysfunction of kidneys or liver, in the presence of severe vomiting or the severe dryness in the mouth, thirst, lethargy, fatigue, sleepiness, anxiety, muscle pains, and so on.
In impaired renal function, frequent monitoring of creatinine clearance is required as the medication may cause a high content of nitrogenous metabolic products in the blood, excreted by the kidneys.
People with liver dysfunction or liver diseases should use the medication very cautiously, since just a small alteration in the water-electrolyte balance, as well as the alterations in the level of ammonium that can be caused by the diuretic, can contribute to the development of hepatic coma.
The medication should be also very cautiously used in severe cerebral and coronary sclerosis.
Where to buy Esidrix at a low price?
To save on the therapy, the best way you can do is to order Generic Hydrochlorothiazide from our online pharmacy. We guarantee the best prices and the highest quality of all medications sold.
Shipping of Hydrochlorothiazide
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