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Generic Reglan (Metoclopramide 10 mg) guide:
What is the drug sold as Reglan?
Reglan is one of the trade names that are officially registered for an active substance called Metoclopramide. The original substance was developed in 1964. As many years had already passed after the medication was first launched onto the market, the exclusive patent of its developer had already expired and you can buy Generic Reglan or simply Metoclopramide made by numerous manufacturers and at quite low prices.
The medication is used in various conditions in which nausea and vomiting are present. You can find more information on when exactly Metoclopramide should be used from our article in the respective section of it.
What is the principle of Reglan’s action?
The medication is a dopamine antagonist that also renders peripheral cholinergic activity. There are two main actions of the medication – anti-vomiting and the acceleration of the transportation of consumed food from the stomach to the bowel. It improves tone and range of the stomach contractions, relaxes the sphincter that connects the stomach to the duodenum, increases motor activity of the stomach and speeds up the depletion of the stomach. Besides, it balances the separation of bile through the elevation of pressure in the gallbladder and bile ducts and therefore contributes to the treatment of gallbladder dyskinesia.
The anti-vomiting effect is due to the impact on the central point of the trunk of the brain responsible for nausea, probably due to inhibition of dopaminergic neurons. You can buy Reglan or a generic version of the drug to cope with nausea caused by chemotherapy of cancer, nausea caused by narcosis, nausea that occurs to the use of medications, for instance, antibiotics, anti-tuberculosis drugs, in diseases of the liver and kidneys, brain trauma, nausea in pregnancy, and so on.
The peristalsis enhancement caused by the drug is partially due to the effect on the specific brain centers, but also a mechanism of peripheral action may be involved in part with activation of postganglionic cholinergic receptors and, possibly, suppression of dopaminergic receptors of the stomach and small intestine.
After the oral intake, the medication is quickly and fully absorbed. Its bioavailability is between sixty and eighty percents. The maximum level in the blood plasma is achieved in thirty minutes to two hours. The start of the action is observed within twenty-forty minutes. The effect of Metoclopramide lasts for around twelve hours.
Can Generic Reglan replace the band drug in the therapy?
The answer is yes, without any doubts. The generic medication made using the same formula and ingredients is not in any way inferior to the brand-name medicine. It is possible for different companies to make the same medicines legally because the exclusive right of the formula developer to make the medication had already expired. The benefit of buying a generic medication is that it is not advertised or promoted and therefore costs less money. You can buy Metoclopramide from this webpage and we guarantee that you will get the same effect from this drug as from the more expensive brand-name one.
When can you get Metoclopramide and start using it?
You can start using the medication for nausea, vomiting, and hiccough of different genesis. In some cases, the medicine can be effective in vomiting caused by radiation therapy or chemotherapy, functional digestive disorders, gastroesophageal reflux disease, weak muscles of the stomach and duodenum, dyskinesia of bile ducts, exacerbation of peptic ulcer of the stomach and duodenum, preparation for diagnostic tests of the digestive tract, and so on.
Reglan or Metoclopramide can be sometimes used in pregnant women in nausea. However, it is advised to use the medication only if your doctor approves and if the expected benefit is higher than the risk.
In general, if you suffer from nausea, vomiting, or any discomfort in the abdomen, make sure to visit a doctor before you buy Generic Metoclopramide as you may end up suppressing the symptoms while neglecting the main disease that can be life-threatening.
When mustn’t you purchase Metoclopramide?
The medication is contraindicated to be used if you are intolerant of its ingredients, bleeding in the gastrointestinal tract, stenosis of the stomach, intestinal obstruction, perforated stomach or bowel walls, glaucoma, pheochromocytoma, epilepsy, Parkinson's disease and other extrapyramidal disorders, prolactin-dependent tumors, and early childhood up to 2 years.
On top of that, it is not recommended to use the medicine if you suffer from bronchial asthma, arterial hypertension, severe liver or kidney failure, and in old age.
What adverse effects can the drug use cause?
Before you order Reglan, you should be ready that in some people it causes certain adverse reactions such as loose stools, dryness of the mouth, fatigue, sleepiness, headache, depression, dizziness, extrapyramidal disorders such as Parkinsonism, and others. If you have any of these effects and they are severe, stop using the drug immediately. If you have an allergy you should also stop using the pills right away as you noticed a skin rash, swelling, or other symptoms.
Do not combine Generic Reglan with the following medicines
Neuroleptic medicines, especially phenothiazines and butyrophenone derivatives, increase the ikelihood of developing extrapyramidal disorders.
The medication lowers the efficiency of Levodopa and Cimetidine.
When combined with medicines that suppress the nervous system and alcohol, the sedative effect increases.
When combined with Cyclosporine, it can slow down the medication’s washing out of the body and the dosage adjustment may be required.
The medication accelerates the absorption of paracetamol and tetracycline.
The medicines containing opioids can contribute to the lack of the effect of Metoclopramide on the peristalsis of the gastrointestinal tract.
If you take any medicines and are not sure whether they interact with Reglan or not, make sure to talk to your doctor about it before you order Generic Reglan.
How to use Generic Reglan?
The medication in a formulation of pills is taken in the dose of 5-10 mg three to four times a day. The maximum single intake dose is 20 mg. The max daily dose is 60 mg. Children aged older than six years can be administered5 mg once, twice, or thrice a day.
The tablets should be taken before meals with sufficient amount of water without chewing. To lower the risk of side effects from the part of the nervous system, the medication is prescribed for short-term treatment up to five days only.
For the prophylaxis and treatment of nausea and vomiting caused by chemo or radiotherapy, the medication is administered intravenously in the dose of 2 mg per kilogram of the body mass 30 minutes before chemo or radiotherapy. If necessary, the administration of the drug can be repeated in two to three hours.
Before X-ray examination, adults are administered intravenously 10-20 mg five to fifteen minutes before the procedure.
People with severe liver or kidney insufficiency at the beginning are prescribed a half of the standard dose. The next dose depends on the tolerance of the medicine by a particular patient.
Please note that at home you can use only tablets. The intravenous injections of the medication can be made only by a certified medical professional.
What should you do if you overdose?
The symptoms of an overdose of the medication are sleepiness, confusion, irritability, anxiety, seizures, extrapyramidal disorders, irregular heartbeat, and others.
In case of the occurrence of symptoms from the side of the nervous system, the symptomatic treatment is prescribed. If you noticed that you overdosed before the symptoms developed, induce vomiting and take activated carbon. If the symptoms had already started to manifest, seek medical assistance as it is important that a doctor monitor a condition of a patient who overdosed with Metoclopramide.
Where can you buy Reglan cheap?
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