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Generic Zanaflex (Tizanidine 2 mg) guide:
What is Zanaflex?
Zanaflex is one of the names Tizanidine muscle relaxant is sold under. The preparation is used in various conditions such as back pain, multiple sclerosis, degenerative diseases of the spinal cord, stroke and with convulsions of central origin, and others.
You can get the same medication when you buy Zanaflex and other medication with the active substance Tizanidine. Splitz, Tizan, Pramiracetam, Sirdalud, Ternelin are only a few names you can find the drug under. Not to remember all of them, you can simply look for Generic Zanaflex as it is the term used internationally to ease the search for needed medications knowing only their widely advertised names. The benefit of buying a generic is that they are usually cheaper than the branded medicines.
When are Zanaflex tablets used?
The preparation is appointed for the fast elimination of painful muscle spasms that occur in conditions of the spine (including osteochondrosis, spondylosis, cervical and lumbar syndromes, and others), after an operation for a herniated disc or osteoarthritis of the thigh, spasms and pain caused by neurological diseases such as multiple sclerosis, chronic myelopathy, degenerative conditions of the spinal cord, cerebral circulatory disorders, stroke, craniocerebral trauma, cerebral palsy, and seizures of central origin.
You can buy Generic Zanaflex if you have an acute pain in the lower back as a result of careless movement to be able to move and go to a doctor for a precise diagnosis. It relieves the pain so that you could move as frequently in severe back muscle spasms people cannot even get out of the bed.
The medication can be taken for a long time without the occurrence of any harm to the body yet it is wiser to get checked if you do have any pain syndrome to discover whether you have a condition that requires comprehensive treatment or only the use of muscle relaxants.
How is the effect of the medication achieved?
Generic Zanaflex’s active substance is a muscle relaxant acting on skeletal muscles of central action, which has a direct effect on the spinal cord, where it suppresses the release of the amino acids that excite certain alpha 2 receptors. Thus, polysynaptic signaling is suppressed at the level of interneuronal connections in the spinal cord (which contributes to excess muscle tone), and the spastic muscle tone is diminished.
Tizanidine is used as an antispasmodic for the relief of acute, painful spasm of muscles and chronic spasticity of cerebrospinal and cerebral origin. It diminishes the opposing to passive movements, suppresses spasm and clonic seizures, and possibly improves the arbitrary muscle strength.
After the intake, the medication is absorbed quickly and almost completely. The maximum concentration in the blood is achieved within one hour after the pill intake. It is metabolized in the liver and excreted in two to four hours predominantly in a form of metabolites
The food intake along with the pills doesn’t influence their effectiveness.
Can you buy Generic Zanaflex instead of the branded drug and get the same effect?
If for some reason you do not want or cannot buy the branded medicine, you can without any doubts buy Tizanidine, i.e. the generic version of the branded drug or simply the same medicine made by different manufacturer. As long as the generic has the same active ingredient and dose per pill of it, you can be sure that it has the same properties and was tested as much as the branded medicine before being released onto the market. The cheaper price is explained by the lack of advertising expenses as generics are not usually advertised or promoted through doctors.
It is possible for generics to be exactly the same as the branded drugs because the formula of the original medication after some time isn’t protected by the exclusive copyright anymore. It allows other manufacturers to do the same pills without infringing any laws.
When is the drug use contraindicated?
Do not buy Tizanidine if you suffer from severe liver dysfunction, asthenic bulbar paralysis; if you are pregnant, breastfeeding or are younger than 18 years. It is also contraindicated to take the medication if you are allergic to it and in combination with certain medicines the list of which you can find in the corresponding section below.
Besides all of this, it is also not advised to use the drug or at least use it very carefully in any liver dysfunction, arterial hypotension (low blood pressure), bradycardia; syndrome of congenital extension of the QT interval; age over 65 years. If you have any heart conditions, it is necessary to regularly monitor the functional state of the heart and do electrocardiography if you take Tizanidine-based medicines.
With what medicines should not you use Tizanidine at the same time?
It is contraindicated to take Zanaflex or any other medication with Tizanidine in its composition along with fluvoxamine or ciprofloxacin.
It is not encouraged to combine the medication use with all inhibitors of CYP1A2 besides the two mentioned above which use along this medication is completely contraindicated. This group of drugs includes antiarrhythmic meds (amiodarone, and others), cimetidine, certain fluoroquinolones (norfloxacin, and others), birth control pills, and ticlopidine.
The medication should be cautiously used along with any medicines that contribute to the elongation of QT interval, for instance, cisapride, amitriptyline, Azithromycin, and others.
It is not recommended to combine Tizanidine with any medicines that lower the blood pressure as their added effects can significantly lower the blood pressure and even lead to a collapse.
The effect of the medication is significantly (around 50%) lowered by the concurrent use of Rifampicin.
Sedatives, sleeping pills, and other medicines such as antihistamines (anti-allergy pills) can enhance the sedative (sleepiness) effect of Zanaflex.
If you use any medications, make sure to discuss their use along with Zanaflex before you order Zanaflex pills and start using them.
Interaction with other substances
Smoking of tobacco lowers the systemic bioavailability of the medication by 30% which is why in some cases in the need of a long-duration therapy it is needed to adjust the doses to achieve the desired effect.
The use of alcohol during the therapy can contribute to the development of such side effects as the depressing effect on the nervous system, lowering of the arterial pressure, and others.
How to use Zanaflex or generic pills?
The medication is taken orally without regard to meals.
To get rid of the pain syndrome caused by a muscle spasm, adults are advised to take 2-4 mg thrice a day. If the effect is insufficient, an additional dosage of 2-4 mg can be taken before sleep.
In muscle spasticity caused by the neurological conditions, the medication should be appointed by a doctor in customized dosages starting from the 6 mg taken thrice a day. The dose is raised gradually once every four to seven days in insufficient effectiveness by 2-4 mg every time. The optimal daily dose usually is 12-24 mg split into three-four intakes. The daily dose must not exceed 36 mg.
The duration of the treatment course with Zanaflex pills is established individually for each patient.
In violation of liver or kidney function the dose of the preparation must be lowered. It is advised to start with the dose of 2 mg once a day. The increase of the dose is made gradually if the starting dosage is inefficient. It is advised to raise the single intake dose and only then increase the number of intakes per day if necessary.
Adverse effects of Zanaflex
In general, the drug is well tolerated but some adverse effects still can develop such as sleepiness, fatigue, dizziness, dryness in the mouth, nausea, insignificant lowering of the blood pressure. High doses can cause muscle weakness, insomnia, significantly lowered blood pressure, bradycardia, and others. If the symptoms are severe, discontinue the drug use and consult a doctor.
When you order Generic Zanaflex without a prescription, you still must be careful with the medication use as an overdose of any medication can cause severe side effects. The symptoms of an overdose of Zanaflex include nausea, vomiting, significant blood pressure drop, QT interval elongation, dizziness, sleepiness, anxiety, violated breathing, and even coma.
If the symptoms are severe, you should seek medical assistance and undergo gastric lavage and drink a lot of water and sorbents (activated charcoal, for instance).
Where can you buy Zanaflex cheap?
As any other medication, Generic Zanaflex is significantly cheaper than the brand-name drug. If you cannot find the medication at a low price at your local pharmacies, order Tizanidine from our online drugstore.
Shipping of Zanaflex
Our med store will ship your order to any place in any country in seven to twenty-five days (express or standard shipping terms).
Our doctor prescribes Tizanidine online for free, and there is no doctor’s consultation fee.
All orders of Tizanidine arrive in discrete unmarked parcels. We leave the shipment description blank.