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Exelon (Rivastigmine 1.5 mg)

Drug description:
Generic Exelon is a kind of medication that is used to treat dementia. According to the instruction, Exelon is selective inhibitor of acetyl and butyrylcholin esterase for brain. The preparation is used to treat Alzheimer disease, dementia and Parkinsonís disease. Taking Exelon (Rivastigmine), you can suppress acetylcholine destruction that is produced by brain neurons. Rivastigmine increases acetylcholine content in brain cortex and hippocampus. This fact improves cholinergic neurotransmission. Exelon makes positive effect in case of cognitive decline, caused by acetylcholine deficit, especially, for dementia as the result of Alzheimer disease and Parkinson disease. There are also many supporting materials about Exelon application to suppress forming of amyloid corpuscles. The amyloid corpuses are the main pathologic symptoms of Alzheimer disease. The daily primary dose is 1,5mg. If the patients are hypersensitive to cholinergic medications, it is recommended to keep the primary dose in form of 1 mg twice a day.
Brand name:
Exelon
Generic name:
Rivastigmine
Manufacturer:
Indications:
Alzheimer disease, dementia, Parkinsonís disease
Benefits:
Suppresses acetylcholine destruction, improves cholinergic neurotransmission, makes positive effect in case of cognitive decline
Analogs:
Rivamer
Exelon (Rivastigmine 1.5 mg)
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Order Exelon (Rivastigmine 1.5 mg)

Dosage:1.5 mg
Quantity (max. 2) Package Price, USD You save
1 90 caps $61.89 $62.51 $0.62
1 180 caps $116.98 $124.65 $7.67
1 270 caps(popular) $173.78 $191.30 $17.52
1 360 caps $228.41 $249.52 $21.11
Price: $168.90

Order Exelon (Rivastigmine 3 mg)

Dosage:3 mg
Quantity (max. 2) Package Price, USD You save
1 60 caps $66.89 $67.32 $0.43
1 120 caps(popular) $118.89 $126.30 $7.41
Price: $168.90

Order Exelon (Rivastigmine 4.5 mg)

Dosage:4.5 mg
Quantity (max. 2) Package Price, USD You save
1 30 caps $39.89 $40.10 $0.21
1 60 caps $66.98 $73.52 $6.54
1 90 caps(popular) $99.98 $113.14 $13.16
1 120 caps $132.98 $148.65 $15.67
Price: $168.90

Order Exelon (Rivastigmine 6 mg)

Dosage:6 mg
Quantity (max. 2) Package Price, USD You save
1 30 caps $44.89 $45.99 $1.10
1 60 caps(popular) $82.10 $86.54 $4.44
1 90 caps $121.89 $132.24 $10.35
1 120 caps $160.29 $182.35 $22.06
Price: $168.90

Generic Exelon (Rivastigmine 1.5 mg) guide:

Exelon pills – what are they?

Clinical Medical Group

Exelon is one of the trade names of the medication substance Rivastigmine that was developed and patented in the early 1990s. Nowadays it is sold under a variety of trade names because the formula isn’t protected by the patent anymore. It means that basically any pharmaceutical company can make the drugs with the same formula as Exelon but they have to name their products differently. Fortunately, you can easily obtain a cheaper version of the medication without even knowing its other trade names if you buy Generic Exelon. This is a standard name used by sellers, pharmacists, and doctors to talk about the other versions of the medications which are sold under other names but have the same composition as the brand-name drug which name is contained in this “code” name.

The active substance of the medication Exelon and its generics is an acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease and dementia in Parkinson's disease. Read further to know when exactly the medication is prescribed and how does it render its effect.

What is the principle of action of Exelon?

Contraindications

The active substance of the preparation marketed under the brand name Exelon is a selective inhibitor of acetylcholinesterase of the brain of the carbamate type. It is considered that it promotes the cholinergic transmission, slowing down the degradation of acetylcholine released from cholinergic neurons with unbroken function. It selectively raises the level of acetylcholine in the cerebral cortex and hippocampus. Thus, it improves the cognitive function impaired due to the failed cholinergic transmission that is present in dementia related to Alzheimer's or Parkinson's disease.

Rivastigmine interacts with target enzymes and forms a covalent binding with them which temporarily deactivates the enzymes. The inhibition of cholinesterase can lead to a delay in the formation of fragments of the protein beta-precursor of amyloid and the formation of amyloid plaques that are characteristic for Alzheimer's disease.

In healthy young men, taking a dose of 3 mg orally reduces the activity of acetylcholinesterase in the cerebrospinal fluid by approximately 40% during the first 1.5 hours. The enzyme activity returns to the initial values at about 9 hours after reaching the maximum inhibition effect. In patients with Alzheimer's disease, the inhibition depends on the dose.

The medication is well-absorbed when taken by mouth. Its bioavailability is around 30-40%. The maximum concentration in the blood is achieved within one hour of intake. The active substance is metabolized by the hydrolysis with the participation of esterases. Then, it is mainly excreted in urine (around 99%) and feces.

According to the studies on animals, the medication doesn’t influence the fetus. However, it is not established whether it penetrates into the breast milk or not. If you expect a baby or breastfeed, you need to consult your doctor before you buy Exelon.

When is Exelon prescribed to be used?

The medication is appointed for the therapy of dementia due Alzheimer’s disease or Parkinson’s disease of mild to moderate stages.
Dementia is an acquired or developed lowering of cognitive functions (thinking, focusing, remembering, etc.), persistent decline in cognitive activity, with the loss, to varying degrees, of previously acquired knowledge and practical skills and the difficulty or inability to acquire new ones.

If you believe that someone from your family suffers from this condition, make sure o consult a specialist before you buy Rivastigmine. Even though we sell all medications without prescriptions we encourage our clients to go to a doctor to find out the precise diagnosis before they order any drugs and start taking them.

When is the use of Rivastigmine contraindicated?

The medication is contraindicated in intolerance of the active ingredients of the pills which is manifested either in moderate to severe adverse reactions or allergic reactions to the pills use, in severe liver dysfunction, and during breastfeeding.

The medication can be used during pregnancy only if the expected benefit is higher than the risks.

The limitations for the use

If a patient who wants to buy Generic Rivastigmine suffers from ulcer of the stomach or duodenum, sick sinus syndrome, conduction disorder (sinoatrial and AV-block), arrhythmias, asthma and COPD (including history), urinary tract obstruction, epilepsy, simultaneous reception of other cholinomimetic agents, or is pregnant, they should render caution when using the drug and necessarily consult a doctor about the safety of the therapy before they start it.

How should Generic Rivastigmine be used?

Dosage and Administration

The treatment must be started under a doctor’s supervision. Preferably, the doctor should be experienced in treating namely dementia associated with Alzheimer’s or Parkinson’s disease. The therapy can be prescribed only to people who have caregivers who can ensure the regular use of the pills.

The pills should be taken twice a day – one dose in the morning and another one in the evening during meals. The pills must be swallowed entirely without chewing.
The initial treatment dose is 1.5 mg two times a day. If the drug is well-tolerated not sooner, in two weeks the dose can be raised to 3 mg taken twice a day. The further rise of the dose to 4.5 and 6 mg taken twice a day is possible only in well-tolerance of the dose and not sooner than with 2-week intervals.

In the occurrence of negative reactions such as nausea, vomiting, pain in the abdomen, loss of appetite or body mass, worsening of extrapyramidal symptoms such as tremor, it is advised to skip one or two doses. If the adverse effects do not fade away, it is advised to lower the dose back to the previous one if it was well-tolerated or suspend the treatment.

If the treatment had been suspended for more than three days, it is needed to resume it with the dose of 3 mg split into two 1.5 mg intakes. Then dose elevation should be made as described above.
The optimal maintenance dose is selected individually and is usually in the range between 3 and 6 mg taken twice a day.
To achieve the maximum effect, it is recommended to take the highest well-tolerated dose. The maximum recommended daily dosage is 12 mg split into two intakes.
The therapy can continue as long as it provides the beneficial effect. A doctor responsible for the patient must regularly assess the effectiveness of the medication. If after three months of the therapy the symptoms of dementia do not diminish, the treatment must be discontinued. Besides, it is needed to revise the reasonability of the therapy if there are no signs of recent improvement of the patient’s condition even if there had been an improvement before.
It is impossible to predict the individual reaction to the therapy with the drug. However, it is statistically proven that the best effect is achieved in people with Parkinson’s with moderately manifested dementia or visual hallucinations.
There are no clinical data on the therapy longer than six months.

Interactions of Generic Rivastigmine with other medicines

Here you can find the most notable interactions but before you order Exelon you should check with your doctor or your caregiver should check with your doctor that you are not using any medicines that also have a potentially negative interaction with this medicine.

The concurrent use of Exelon or its generics with Metoclopramide can increase the risk of extrapyramidal side effects.
Rivastigmine can enhance the cholinergic effects of other cholinomimetic drugs, when used simultaneously with anticholinergic drugs, for instance, oxybutynin, Tolterodine, and others, the antagonism of the action can occur (they interfere with each other’s effects). In general, the simultaneous use of the preparation with drugs that affect cholinergic structures is not recommended.
If the medication is used along with beta-blockers especially cardioselective ones, there is a risk of enhanced heart side effects. Therefore, it is not recommended to take Exelon along with beta-blockers.

What side effects can Generic Exelon cause?

Drug Interaction

The drug use can cause the onset of such adverse effects as increased fatigue, dizziness, headache, sleepiness, agitation, depression, tremor, nausea, vomiting, diarrhea, pain in the stomach, loss of appetite, heartburn, allergic reactions, increased sweating, and others.
When you order Generic Exelon, you should know that it can increase the production of gastric juice and related side effects can develop.
Some of the side effects that already developed can be eliminated with the skipping of one or several doses of the preparation. If they still persist after the therapy is resumed, it is indicated to lower the dosage back to the maximum one which was well-tolerated.
In case of the occurrence of allergic dermatitis in patients, treatment with Rivastigmine should be discontinued.

Overdose sins and therapy

Overdosing

The symptoms of an overdose are nausea, diarrhea, and vomiting.
The therapy includes the suspending of the treatment for 24 hours and the use of anti-vomit medications and other the symptomatic therapy if needed.

Where can you buy Exelon cheap?

The drug is sold at the regular drugstores but people who want to buy it cheaper should order Rivastigmine from an online med store like ours. Our benefits are cheaper prices because of lower operating expenses and the possibility to sell medicines without Rx. We are able to do so because our office and warehouses are located in the country where these medicines are over-the-counter ones.

Shipping of Exelon

Generic Exelon (Rivastigmine) Shipping by Rxshop

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Free prescription

Our doctor prescribes Rivastigmine online for free, and there is no doctor’s consultation fee.

Discrete packaging

All orders of Rivastigmine arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

Exelon (Rivastigmine) Reviews:

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