Pletal (Cilostazol 100 mg)
Generic Pletal (Cilostazol 100 mg) guide:
What is Pletal?
Pletal is a copyrighted name registered for the selling of the active substance called Cilostazol. It was developed a long ago and is no longer made by a single pharmaceutical company yet other companies cannot use the same trademark for their drugs which is why you can find numerous medications with the same composition looking for Generic Pletal. It is an internationally-used and understood name for other medications based on Cilostazol but it cannot be registered. Therefore, you can buy the same drug under the names Pletoz, Pletaal, and many others.
The medication is used for the enhancement of the capability to carry out physical activity in intermittent claudication. You can find out more about how the medication acts from the sections below before you buy Pletal.
What’s the principle of Pletal effect?
The medication is a reversible inhibitor of the aggregation of platelets. It inhibits the substances that promote the aggregation including arachidonic acid, collagen, adenosine diphosphoric acid, and adrenaline. The inhibition lasts for twelve hours and after the discontinuation of the therapy is back to the initial levels within two to four days. Besides, the drug affects lipids that circulate in the blood plasma. It lowers the levels of triglycerides and elevates the level of high-density lipoproteins (good cholesterol).
Pletal’s active substance, Cilostazol, has a vasodilator effect (promotes the dilatation of blood vessels) in the lower limbs, inhibits the proliferation of smooth muscle cells and platelet-derived growth factor and PF-4 release in human platelets.
Through all this, the preparation enhances the capability to carry out physical load by people with intermittent claudication as it decreases the pain syndrome and improves general lower limbs condition.
According to the clinical trials with different loads, it had been established that the medication provides an absolute significant improvement by forty-two meters of the max walking distance compared to placebo. This effect is also observed in people with diabetes type II but the improvement is lower.
In the regular use of Generic Pletal in the dose of 200 mg a day, people with peripheral blood vessel diseases achieve a stable condition within four days.
If you think that in your condition the preparation use would be reasonable, you can buy Generic Pletal from this web page without Rx but we still advise you to talk to your doctor first.
When can be the therapy with Generic Pletal used?
The medication use can be prescribed as a part of the maintenance therapy after a surgery to that implied stent introduction and for the improvement of symptoms of intermittent claudication.
Intermittent claudication is a growing pain syndrome in the legs that arises from the background of physical activity (walking, lifting, running) and passes after a short rest. This type of pain occurs in a long-term, or chronic, the form of blood flow disturbance in arterial vessels and, as a consequence, insufficiency of blood supply to tissues. If you think that you may be suffering from this conditions, especially if you are older than fifty and have this symptom, make sure to visit your doctor as soon as possible and if your he or she advises you to use Pletal, you can buy Cilostazol that is the same medication simply made by another drug-manufacturing company cheaper at our online pharmacy.
Note that the medication is mainly prescribed as a second-line treatment if the changes in the lifestyle such as smoking cessation, the introduction of physical exercises, diet, and so on do not improve the condition significantly.
Currently, the medication is also tested for the use for the purpose of prevention of repeated stroke, thrombosis, and repeated stenosis after reconstructive vascular surgery, as well as for the treatment of the post-stroke syndrome.
When is Generic Pletal use contraindicated?
The contraindications for the medication use include the hypersensitivity to Cilostazol or other components of the pills, severe renal dysfunction with cc less than 25 ml per minute, moderate to severe liver insufficiency, heart failure, pregnancy, predisposition to bleeding, proliferative form of diabetic retinopathy, uncontrolled hypertension, tachycardia, ventricular fibrillation, or multilocular ventricular ectopia, regardless of whether they received appropriate treatment, extension of the QT interval.
If you haven’t checked your health for a long time and are not sure whether you have any of the above-listed conditions, make sure to undergo a comprehensive medical examination before you buy Generic Cilostazol and start the therapy.
How must the Generic Pletal be used?
The recommended daily dose of the medication is 200 mg split into two intakes. The pills should be taken a half an hour before a meal or two hours after a meal in the morning and in the evening.
If the pills are taken with food, the level of the active substance in the blood can raise which can possibly cause the occurrence of side effects.
In mild renal (cc more than 25 ml per minute) or liver insufficiency, the adjustment of the dosage is not required.
People of old age do not require dosage adjustments unless they suffer from severe liver or renal insufficiency in which case the use of the drug is contraindicated for them.
The medication is not advised to be used in children as there is no sufficient data on the safety of the drug use in this group of patients.
The substantial improvement of the condition is observed after the use of the preparation for four to six months without interruptions. Sometimes the significant improvement is noted already in one to three months. But if the therapy hadn’t provided any substantial changes within six months, a doctor must choose another therapy plan.
What negative reactions can Generic Pletal cause?
When you order Pletal, you must be prepared that the medication can cause certain adverse effects such as bruising; anemia, prolonged bleeding time, tendency to bleeding, thrombocytopenia, allergic reactions, edema, diabetes, anorexia, diarrhea, stool disorder, nausea, vomiting, dyspepsia, flatulence, abdominal pain gastritis, anxiety, headache, dizziness, sleeplessness, paresis, palpitations, tachycardia, angina, arrhythmia, myocardial infarction, heart failure, loss of consciousness, ocular hemorrhages, hot flashes, hypertension, hypotension, subcutaneous hemorrhage, and others.
The likelihood of these negative effects is not high yet if you develop bruises, bleeding, or notice that the blood from cuts takes much longer time to stop flowing, you should inform your doctor immediately and possibly even stop using the drug. The medication indeed increases the risk of bleedings as it suppresses the platelet aggregation. It is important to keep it in mind and inform your doctor if you are about to undergo a surgery. It is, in general, advised to stop using the drug five days before surgery, including dental surgery.
Interaction of Pletal with other drugs and non-medical substances
When you order Generic Pletal, you should keep in mind that if you take any other medications, they can be either incompatible with this drug, lower its effect, or their effect can be lowered by Pletal. The reason for that is that the medication is metabolized with the effect of enzymes ?450 - CYP3?4, CYP2?19, and CYP1A2 which also participate in the metabolism of many other drugs. Therefore, you must inform your doctor about all drugs that you currently use or plan to start using with Pletal so he or she would advise you on the dosage adjustments, changes in the therapy, and so on. The most notable negative interactions can develop on the basis of the concurrent use of Cilostazol with erythromycin, clarithromycin, antifungal agents such as ketoconazole, itraconazole, calcium antagonists, benzodiazepines, and others.
The medication must be cautiously used with any other medications that can contribute to the blood pressure lowering as there is a risk of additive hypotensive effect associated with reflex tachycardia.
Generic Pletal must be cautiously used with any other anticoagulants.
During the clinical trials, it had been also discovered that tobaccos smoking decreases the concentration of the drug in the blood plasma by 18% which also affects the effectiveness of Generic Pletal.
There is limited data on an acute overdose. Potentially, it is considered that it can cause a severe headache, diarrhea, tachycardia, and arrhythmia. The first measures are to induce vomiting and perform gastric lavage.
If you have these symptoms, you should seek medical assistance as you need a supporting therapy at a hospital.
You must inform your doctor about any signs that can develop on the basis of early pathological changes of the blood such as hyperthermia (feeling of heat), an ache in the throat, and others (ask your doctor about them). If your doctor suspects any changes in the blood composition, he or she must appoint you a full blood test. If the test shows that you indeed have pathological changes, you must stop using the drug.
The preparation can cause dizziness. Therefore, during the first days of the therapy, it is advised not to drive vehicles to see how you tolerate the drug.
Where can you buy Pletal?
If you need to take the medication for a long time, you can order Cilostazol pills from our online pharmacy at a fraction of the brand-medication price and get the same treatment results.
Shipping of Pletal
We will ship your order wherever you are as we specialize in the international selling of the medications.
Our doctor prescribes Cilostazol online for free, and there is no doctor’s consultation fee.
All orders of Cilostazol arrive in discrete unmarked parcels. We leave the shipment description blank.