Seroquel (Quetiapine 25 mg)
More facts about Generic Seroquel (Quetiapine 25 mg):
Generic Seroquel (Quetiapine 25 mg) guide:
Seroquel and its generics overview
Seroquel pills are medications based on Quetiapine. Quetiapine is an internationally acknowledged and used name for the preparation while Seroquel is nothing more than a trade name copyrighted by a certain pharmaceutical concern. Since the active substance of this branded medication was developed back in 1985, nowadays it is also available under other trade names because it can be made by different producers but they have to copyright their own trademarks to be able to sell the drug. These versions of the medication are cheaper so if you want to buy Seroquel at a low price you should get the medication named differently but make sure to check that its active ingredient is Quetiapine. You don’t have to do a research to find out other names under which the drug is sold as you can easily find it if you look for Generic Seroquel. This is the term used for all drugs with the same composition and formula as the branded one and is understandable for most pharmacists, doctors, and so on.
Seroquel, or more precisely its active ingredient Quetiapine, is an atypical neuroleptic (antipsychotic) drug used to treat mainly chronic and acute schizophrenia, but it can be also used for some other mental illnesses more about which you can find out in the respective section of this guide.
How does Seroquel act?
The main agent renders an antagonist effect on a large number of receptors-neurotransmitters of the brain. It has a similitude with serotonin, dopamine, histamine, and adrenergic receptors.
The antipsychotic and rare extrapyramidal effects of the substance are presumably associated with a particular combination of antagonistic effects on receptors.
The sleepiness associated with the drug use is explained by its high affinity to the histamine receptors. In the same manner, the cases of orthostatic hypertension (sharp decrease in the arterial pressure when standing up) in the administration of high Quetiapine doses are explained by the medication’s high affinity to alpha-one-adrenergic receptors.
In the combined use with the mood stabilizers, the medication is effective in the prophylaxis of exacerbations of manic and depressive phases in bipolar disorder of type I, especially notably is reduced the risk of depression episode relapse.
If you believe that you or someone from your family needs to buy Generic Seroquel and start using it, you can do so by ordering the pills online from this webpage without a prescription but it is highly encouraged to go to a doctor and do all necessary tests first to be sure in the diagnoses and correctness of the chosen therapy.
The length of the preparation’s effect
The clinical trials demonstrate that the most effective regimen of the drug use is two times a day. It is confirmed by the fact that the action of it on 5-HT2- and dopamine receptors lasts for twelve hours.
Absorption and metabolism
In the oral use, the drug is quite well absorbed. The food intake doesn’t significantly affect the bioavailability of the preparation. The highest blood concentration of the preparation is achieved within one and a half hours after the pill intake.
Generic Seroquel is mainly metabolized in the liver through sulfoxidation and oxidation. Nearly 75% of it is excreted in urine and around 20% in feces.
The average washing out rate of the preparation in senior patients is by thirty to fifty percent lower than in people aged from eighteen to sixty-five.
When is Generic Seroquel use indicated?
The medication is appointed for the management of schizophrenia, manic and depressive phases of bipolar disorder type I and II as well as a prophylaxis of the relapses. Besides, it can be used as a part of complex therapy for major depressive disorder and organic psychotic disorders.
If you are diagnosed with one of the conditions you can buy Quetiapine right away from our online pharmacy but it would be wiser to consult your doctor first to be certain that this medication is what you really need.
When must not Generic Seroquel be utilized?
The drug use is contraindicated in hypersensitivity to any components of the pills. Besides, since there is no sufficient data on the safety of the medication for the fetus or an unborn baby, it is allowed to administer the drug to women expecting a baby only if the expected benefit is higher than the risk. The same is with the breastfeeding; it is unknown whether the substantial amount of the drug penetrates into the milk. Therefore, it is advised to transfer a baby on the formula feeding if the mother needs to use Seroquel or any other drug based on Quetiapine.
On top of that, it is prohibited to combine the medication with certain other drugs. Find out more details in the respective section further in the guide.
Probable negative effects of Quetiapine
Based on the tests, this medication is one of the most well-tolerable and safe drugs among atypical antipsychotics. The most frequent negative effects it can provoke are sedation, sleepiness, orthostatic hypotension, lightheadedness, dyspepsia (indigestion), and others. Usually, if these negative reactions develop, they can be easily eliminated with the lowering of the single dose.
Drugs not to combine Quetiapine with
The medication use is contraindicated if you use the inhibitors of P450 3A4 cytochrome such as inhibitors of HIV-protease, erythromycin, Clarithromycin, certain medications to treat fungal infections, and nefazodone. Verify with your therapist that you don’t use any of these drugs at the moment you buy Generic Quetiapine.
The use of Seroquel along with Phenytoin, or other inducers of hepatic enzymes such as Carbamazepine, barbiturates, Rifampicin, thioridazine, and others can cause the increased washing out of Seroquel. Therefore, the rise of the doses can be needed. And if the drugs’ use is discontinued, the respective dosage lowering of Seroquel should be done.
It is advised to render caution using Seroquel with other medications and substances (including alcoholic beverages) that influence the central nervous system.
During the therapy with Quetiapine, it is not encouraged to drink grapefruit juice.
How to use Seroquel or Quetiapine?
It is the best way to order Seroquel and take or administer to your family member who is prescribed the drug only when a doctor prescribes it and gives precise instructions on how to take the pills. However, here you can find the general recommendations for the preparation use that are available publically.
The pills should be taken twice a day regardless of the meal intakes.
For schizophrenia management, the regular daily dose regimen for the first 4 days is the following: at the first day the dose is fifty mg, at the second day the dose is one hundred mg, at the third day the dose is two hundred mg, and at the fourth day the dose is three hundred mg.
Starting from the fourth day, the dose must be gradually raised till the regular best dose in the range from 300 to 450 mg a day split into two intakes. Contingent on the efficiency of the medication in a certain patient and presence or lack of side effects, the dose can be adjusted in the range between 150 and 750 mg a day.
The transition from one daily dose to another happens within two days since during one to two days the equilibrium quantity of the medication in the body is still not achieved. In the need of adjusting the dose, it is recommended to change it every time on25-50 mg.
For bipolar manic disorders management the regular daily dose regimen for the first 4 days is the following: at the first day the dose is one hundred mg, at the second day the dose is 200 mg, at the third day the dose is three hundred mg, and at the fourth day the dose is four hundred mg. The further rise of the dose till eight hundred mg a day should be made gradually with the rise of the daily dose not more than on two hundred mg. The daily dose must be split into two intakes. The perfect dose for a certain patient is chosen based on the individual reaction and tolerance.
The doses for other mental disorders including major depressive disorder are chosen individually at a doctor’s discretion.
Dosages for people older than 65 years
As any other antipsychotic, Seroquel must be cautiously used in this category of patients especially at the beginning of the therapy. The therapy should begin with 25 mg a day split into two intakes. Then, the dose can be raised every day by 25-50 mg till the achievement of the effective dose which is likely to be lower than for the patients of younger age.
Dosages for people with impaired liver function
This category of patients also should take the medication cautiously. The therapy should be started with twenty-five mg a day split into two intakes. Then, the dose can be raised daily by twenty-five to fifty mg till the achievement of the effective daily dose.
What happens if you miss the dose?
When you order Generic Seroquel you should pay attention to the dosage regimen and strive to avoid missing the doses as the preparation is effective namely when taken two times a day. You should take the pills at the same time every day. In case you missed the dose, you should take it asap if it’s not already time for the next dose intake. In that case, skip this dose and continue the therapy in a regular way. It is prohibited to take two doses of the drug at once.
Overdose danger and treatment
The most dangerous the overdose of the substance is for people with cardiovascular disorders. The most frequent negative symptoms that can develop after Generic Seroquel overdose are the enhancement of the drug’s side effects such as sleepiness, sedative effect, tachycardia, arterial hypertension, QT interval extension, seizures, suppressed breathing, urinary retention, confusion, and others.
There is no specific antidote for the medication overdose. In severe poisoning, it should be noted that the medication may be overdosed along with other substances. If the negative symptoms develop and become severe, you must seek emergency help and undergo symptomatic treatment as well as vital functions maintenance at the hospital.
Where can you buy Generic Seroquel?
In the majority of countries this medication is sold with a prescription only but not in all. Our online pharmacy is located in the country where you can order Quetiapine without a prescription and save money both on the medication and visits to your doctor for new prescriptions.
Shipping of Seroquel
We ship all medications including Generic Seroquel internationally. You can opt for a standard shipping to save maximally or choose express delivery to get the pills within a week wherever you are.
Our doctor prescribes Quetiapine online for free, and there is no doctor’s consultation fee.
All orders of Quetiapine arrive in discrete unmarked parcels. We leave the shipment description blank.