Zyloprim (Allopurinol 100 mg)
More facts about Generic Zyloprim (Allopurinol 100 mg):
Generic Zyloprim (Allopurinol 100 mg) guide:
What is the drug sold under the name Zyloprim?
The medication mostly marketed in the U.S. under the brand name Zyloprim was first discovered in 1956. Then it was developed as an antitumor agent but it didn’t show the effect that was expected from it. However, it deemed effective in the treatment of gout. It was first patented and used for the condition in 1966. Later, the exclusive patent of the developer expired and the medication started to be produced by different companies under different names but the active substance Allopurinol is always indicated on the package of pills. Therefore, if your doctor tells you to buy Zyloprim, you can always opt for its cheaper analogs.
The active substance of the medication violates the synthesis of uric acid. It renders urostatic action, i.e. it lowers the level of uric acid in the body and promotes the dissolution of urates. Therefore, the medication is prescribed in the conditions associated with an abnormally high level of uric acid in the blood that cannot be managed with diet exclusively such as gout, uric stone disease uric acid nephropathy, and other conditions.
Allopurinol is metabolized by xanthine oxidase into its active metabolite oxypurinol that also is an inhibitor of xanthine oxidase. The active agent is almost completely metabolized within 2 hours after the oral intake. Then oxypurinol is slowly excreted with the urine within 18-30 hours. The active metabolite oxypurinol is responsible for all effects of the medication.
What is Generic Zyloprim?
Generic Zyloprim is the same medication as the branded drug simply made by another pharmaceutical enterprise. It Is possible thanks to the program of the World Health Organization that promotes the making of affordable medications and sharing of the formula between the pharmaceutical companies to ensure the satisfaction for the medications demand and affordability of the medication for all people including the developing countries. However, currently with the high prices of all medications, generics become very popular in the developed countries too. Only a small percentage of people still opt for branded medications due to their belief that they are more potent and safe. In fact, it is not so. This idea is promoted by the doctors who are paid to tell so their patients by the large pharmaceutical companies who intentionally overprice their medications even if they returned the cost of research and production multiple times. Therefore, not to be the victim of this unfair play, you can buy Generic Zyloprim instead of the branded medication and enjoy absolutely the same treatment.
When should you buy Generic Zyloprim?
Obviously, the best time to purchase the medication and start the therapy is when your physician tells you to do so. However, if you are unsure that your treatment helps and you are diagnosed with one of the conditions this particular medication is used for, you can yourself propose your therapist to include Allopurinol in your therapy.
The preparation is used for conditions and diseases with hyperuricemia or an abnormally high level of uric acid in the blood that cannot be managed with diet exclusively such as gout, uric stone disease uric acid nephropathy, secondary hyperuricemia of various genesis, primary and secondary hyperuricemia in hemoblastosis (lymphosarcoma, acute leukemia, chronic myelogenous leukemia), congenital enzymatic deficiency (including Lesch-Nyhan syndrome and congenital adenine phosphoribosyltransferase deficiency).
When must not you buy Zyloprim?
You should not buy Allopurinol and start using it if you are allergic to the ingredients of the pills, severe liver or kidney insufficiency, are pregnant or breastfeeding.
In Pediatrics, the medication can be used only in children older than 15 years.
The medication must be cautiously used in people with mild to moderate liver and kidney insufficiency, hematopoietic disorders, heart failure and arterial hypertension, which are treated with angiotensin-converting enzyme inhibitors or diuretics.
The medication is not prescribed for people with acute gout. Besides, after the acute episodes are treated, the therapy should be started with caution as it can cause exacerbations.
If your work requires concentration, for instance, driving or operating of large machinery, you should carefully take the pills and avoid if possible such activities as the preparation can cause sleepiness and dizziness.
How to take Generic Zyloprim?
If you don’t have a precise prescription from your health care provider how to take the pills, you can follow this guide when you buy Generic Allopurinol but you should note that the conditions it is used for require constant monitoring of the uric acid level and other indicators for a successful therapy.
The pills should be taken orally without chewing and swallowed with a sufficient amount of water. It is advisable to take the pills after a meal. After you took the pill, you need o drink a lot of water to maintain normal diuresis.
The daily dosage is calculated based on the level of uric acid in the blood plasma. The average daily dosage is 100-300 mg of the medication. It can be taken in a single intake. It is recommended to start the therapy with the minimum dose of 100 mg once a day and if needed, raise it till the effective one but not more than 800 mg a day which is a maximal safe dosage per day. The dosage raise can be done once in one-three weeks based on the level of uric acid in the plasma.
The average supporting dosage a day is 200-600 mg. In some cases, higher dosages of 600-800 mg a day are needed. If the daily dosage is more than 300 mg, it should be split into several intakes.
In the dose raise, the level of oxypurinol, the active metabolite of Allopurinol should be monitored. It must not exceed 15 micrograms per milliliter.
The dosage for children is calculated based on the body mass. Usually, 10-20 mg is administered per kilogram of the body weight. The daily dosage must be split into three intakes.
The maximum daily dosage for children older than 15 years is 400 mg.
In the therapy of urolithiasis and gout, the amount of urine for a day should be not less than two liters.
Dosage adjustments for certain groups of patients
Patients with kidney insufficiency should take 100 mg a day. If the dosage is insufficient, it can be gradually raised but with strict control of the level of oxypurinol in the blood plasma.
Patients with creatinine clearance over 20 milliliters per minute should use not more than 300 mg per day.
Patients with creatinine clearance from 10 to 20 milliliters per minute should use not more than 200 mg per day.
Patients with creatinine clearance lower than 10 milliliters per minute should use not more than 100 mg per day. If necessary, the dosage can be increased but the intervals between the intake are also increased, for instance, 100-300 mg are taken every 48-72 hours.
Patients on hemodialysis are recommended to use 300-400 mg after each dialysis 2-3 times a week.
What adverse effects can Allopurinol cause?
The medication rarely causes adverse reactions but still, you should be ready that some of the negative symptoms can occur such as nausea, lowering of blood pressure, bradycardia, sleepiness, dizziness, and others. In case you take medication for gout, in the beginning of the therapy the symptoms of the disease can worsen.
It doesn't matter what symptoms you have when you order Zyloprim and start taking the pills. If any deviations from your normal condition arise, you should inform your physician.
Interaction with other medications
The pills can negatively interact with other medicines that you take. For instance, lower the effect of certain medications and on the contrary enhance the effect of other provoking the occurrence of adverse reactions. Therefore, before you order Generic Zyloprim you should discuss with your healthcare provider the possibility of medications concurrent use if you already take any meds or plan to start taking them along with this preparation.
Overdose with Generic Zyloprim
The medication overdose can cause nausea, vomiting, dizziness, stool violation, and other symptoms. There is no antidote for the drug and symptomatic therapy is prescribed.
Where to buy Zyloprim?
You can get the medication at any local drugstore or, if you need to take it for a long time, order Allopurinol from our online pharmacy. This will save you a lot of money and time on the visits to a doctor and pharmacy.
We will ship your order to any corner of the world within 7-25 days depending on the delivery method of your choice.
Our doctor prescribes Allopurinol online for free, and there is no doctor’s consultation fee.
All orders of Allopurinol arrive in discrete unmarked parcels. We leave the shipment description blank.