Retin-A (Tretinoin 0.025%/20 g)
More facts about Generic Retin-A (Tretinoin 0.025%/20 g):
Generic Retin-A (Tretinoin 0.025%/20 g) guide:
What is this Retin-A drug?
Retin-A is a commercial name for the active substance Tretinoin which is basically vitamin A in a form of carboxylic acid also known as fully trans-retinoic acid. It is a first-generation retinoid, commonly used to treat acne and follicular keratosis and sold in the form of creams or gels under a variety of trade names. The name Retin-A is protected by the copyright and can be used only be the company that registered it which is Johnson and Johnson but it can be found if you look for Generic Retin-A. Then it will have another name on the tube but if the active ingredient is Tretinoin than you can be sure that you get the right medication. However, you should also pay attention to the concentration of the active substance in the ointment or gel. The most commonly used concentrations are 0.025 %, 0.05 % and 0.1 %.
When can you buy Generic Retin-A and start using it?
The medication comes in various forms and you should carefully use the one that will be suitable for you, preferably, consult a healthcare specialist before you buy Retin-A.
The tablets based on Tretinoin are used acute promyelocytic leukemia (for the induction of remission / temporary weakening or elimination of disease manifestations) both in patients who have not received previous therapy, in relapses (repeated appearance of signs of the disease), or irresponsiveness to standard therapy with rubomycin or cytarabine.
The gel based on the active substance Tretinoin, including the well-known Retin-A, is used for the topical use in diagnosed acne vulgaris, including the formation of comedones (sebaceous plugs in the mouth of the hair follicles), papules, pustules (bubbles on the skin filled with pus), and the disease nodular cystic skin elastosis with comedones.
How does Tretinoin render its effect?
The medication is included in the group of retinoids, structurally close to vitamin A, is a natural metabolite of retinol.
In local application, penetrating through the cell membranes, it forms a cytoplasmic complex that enters the cell nuclei. The resulting hormone-receptor complex binding to DNA interferes with transcription and thereby disrupts protein synthesis. This mechanism underlies the hypopigmented activity of tretinoin. Stimulates the mitosis of the epidermal cells, increases the number of glycosaminoglycans, elastic fibers in the papillary layer of the skin, inhibits melanogenesis, increases the growth and differentiation of epithelial cells, and inhibits the adhesion of cells that form acne.
When treating open acne with the gel, it promotes the smoothing of the skin surface without signs of inflammation. When it is applied to the closed acne, it helps them open or pass into the papules with subsequent healing (without scarring). Besides, it prevents the formation of new acne. Has anti-seborrheic, anti-inflammatory, keratolytic, and immunostimulating action. The therapeutic effect develops 6-7 weeks within the treatment of acne, the maximum effect is usually observed at 8-12 weeks of treatment.
When is the mediation use contraindicated?
The medications based on Tretinoin both those that are used orally and topically are contraindicated to be used in hypersensitivity to the drug. For the topical use of the cream or gel, there is also a contraindication related to the acute inflammatory disease of the skin such as dermatitis, rosacea, wounds, skin burns, photosensitivity, and rectum diseases.
The medication is strictly contraindicated in all forms for the use in pregnant women as it causes severe damages to the fetus. If a breastfeeding woman wants to buy Tretinoin and start using it, she must transfer the baby to the formula.
The drug must be carefully used in women of childbearing age who do not use reliable contraception (a talk with a doctor is required), in people with elevated intracranial pressure, hypercholesterolemia, hypertriglyceridemia, leukocytosis, impaired liver and kidney function, pancreatitis, diabetes, chronic intoxication (including alcoholic), age over 50 years, and in children (up to 1 year for the oral intake and up to 12 years - with local use).
What adverse effects can Tretinoin cause?
In the local application of the medication for the treatment of acne, such adverse reactions as redness, burning sensation, skin peeling at the site of application; in rare cases swelling, blistering or crusting, and photosensitivity (increasing the sensitivity of the body to sunlight) can occur.
On this webpage, we offer you to buy Generic Tretinoin in a form of a skincare product. If your doctor prescribes you the pills based on Tretinoin you should read the full instruction that accompanies the pills as it includes a whole list of possible adverse effects and dangers of the pills use.
How to use Retin-A cream?
Here you can find the instruction for use suitable when you buy Generic Retin-A for topical external use. Please read the instruction on the pills if you need to use them.
The cream or gel is applied on the affected areas in a very thin layer once a day and leave it there for six hours. Then, it should be rinsed off with running water.
For people with light and dry skin, while the drug is on the skin, it is advised to not get direct sun exposure for more than thirty minutes at the beginning of the treatment. Subsequently, this time can be extended.
During the treatment, it is allowed to carefully remove completely softened comedones and pustules. Duration of the treatment usually is from one week to three months depending on the severity of the condition. For preventive purposes, the drug is applied 1-3 times a week for a long time after a warm bath.
Make sure that when you apply the preparation on the skin it doesn’t get into your eyes, mouth, and mucosa. If it gets in these areas – rinse it off immediately.
During the therapy, it is recommended to avoid direct sun exposure. People who have suntan should start the therapy after the tan is off. If during the therapy the sun exposure is inevitable, you should use potent sunscreen.
During the first week of the therapy, the acne can exacerbate which is related to the effect of the preparation on the deep-rooted acne which was not seen before the therapy.
Interactions of Tretinoin
The medication is not compatible with tetracyclines as in their concurrent use the risk of elevated intracranial pressure increases.
The medication must not be used along with oral contraceptives with progesterone as it lowers their effect.
It must not be combined with the use of vitamin A as well as the medications that increase sensitivity to light such as sulfonamides, thiazide diuretics, phenothiazines, cosmetic products that cause skin dryness or irritation.
Ketoconazole and other drugs that affect hepatic cytochrome oxidase, increase the concentration of Tretinoin in the plasma.
The above-listed contraindications are for the oral use of the drug. If you want to order Tretinoin in a form of oral medication, please make sure to talk to your doctor if you use any of the medications listed or any other drugs.
In the topical application of the medication, the risk of adverse reactions increases in the use of retinoid-containing substances, as well as prolonged exposure to the sun, a hot climate, UV irradiation.
The topical form of the drug must not be used in benzoyl peroxide and antibiotics.
When using the medication topically, it is recommended to protect the areas on which the drug is used from the action of sunlight and artificial UV, wind, and cold. People who are tanned need to wait till the tan fades till they can start applying the medication.
If the ointment gets on the mucosa or in the eyes, rinse it off immediately.
Where can you buy Retin-A ointment?
You can acquire the medication from your local drugstores either in a form of the brand-name drug which is more expensive or get the generic version. However, regular drugstores usually set higher prices than the online ones. Therefore, if you want to save as much money as possible while getting the best treatment, you should order Retin-A from our online pharmacy.
Shipping of Retin-A ointment
You can order the delivery of the product to any corner of the world via express or standard shipping method.
Our doctor prescribes Tretinoin online for free, and there is no doctor’s consultation fee.
All orders of Tretinoin arrive in discrete unmarked parcels. We leave the shipment description blank.