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More facts about Generic Chantix (Varenicline 1 mg):
Generic Chantix (Varenicline 1 mg) guide:
What is the medication sold under the name Chantix?
The medication sold in the U.S. as Chantix is known worldwide mostly as Champix. Both medicines are based on the substance called Varenicline that was discovered in the early 2000s by Pfizer and patented for the nicotine dependence treatment (cigarettes smoking). For the first time, the medication was marketed in 2006.
It helps people even with long-term dependency on tobacco to quit smoking. The mechanism of action of the drug and what makes it more effective and different than the other smoking cessation aids are described below.
If in your country the drug is very expensive, you can buy Chantix from our online pharmacy.
How the medication acts and is it more effective than other smoking cessation aids?
Varenicline with high affinity and selectivity binds to Alfa4Beta2-nicotinic acetylcholine receptors of the brain for which it is both a partial agonist (but to a lower extent than nicotine) and an antagonist in the presence of nicotine.
Nicotine binds to the same receptor place to which Varenicline has a higher affinity. Thus, the medication effectively prevents nicotine from stimulating these receptors and activating the dopamine system, the mechanism that on which the formation of nicotine dependence is based.
The efficiency of the medication as a means for nicotine smoking cessation is due to its partial agonism against nicotinic receptors, binding to which diminishes craving for smoking and eases the withdrawal syndrome while leading to a decrease in the sense of pleasure from smoking (antagonism in the presence of nicotine).
The effectiveness and safety of the medication use were studied in three-phase studies. During the studies, its effectiveness was compared to the effectiveness of nicotine-replacement therapy. During the six-week study, the effectiveness of nicotine-replacement therapy was observed only in 16% of people while the results of two twelve-week studies of Chantix were 44% and 64%.
In the direct comparative study of the smoking cessation aids, Varenicline’s effectiveness also surpassed nicotine-replacement therapy. Therefore, if you struggle with cigarettes smoking cessation, you should buy Generic Chantix and give it a try even if nothing else helped you.
The maximum concentration in the blood is achieved within three-four hours after the dose intake. The equilibrium state was reached within four days.
The medication is quickly and almost entirely absorbed without regard to meals and the time of the day.
In the body, the medication undergoes a minimum transformation, i.e. it is almost completely excreted from the body in an unchanged form.
Advantages of smoking cessation with Chantix
The medication should be used with the plan of quitting smoking within the next one-two weeks of intake. However, it is possible for people who do not want to set such goal to choose their own smoking cessation date within the next five weeks after the therapy is started.
In the research during which some groups of people used a placebo and others the real drug, among people who didn’t want to quit smoking within four weeks but who wished to lower the number of cigarettes before they quit the higher level of level of persistent abstinence compared with placebo-users was noted.
When you buy Varenicline you should not worry that your condition in case you suffer from the chronic obstructive pulmonary disease can worsen. It is proven that the medication is safe for this group of patients.
For whom the drug is contraindicated?
The drug is prohibited to be used by people who suffer from severe adverse effects from its use, i.e. are hypersensitive to its components, in the terminal stage of renal failure, during lactation, and in people younger than eighteen years.
There hadn’t been any adequate and controlled studies of the use of the medication in pregnant women. Therefore, you must not buy Generic Varenicline and use it while carrying a baby.
There are no data on the penetration of the medication into the breast milk. If the medication must be used by a breastfeeding woman, she must transfer the baby to a formula feeding.
How to use pills of Chantix?
If the medication is not contraindicated for you, you can follow the below-described instructions for its use.
The pills are taken orally regardless of mealtime. The recommended therapeutic dosage of the medication is 1 mg taken twice a day. But during the first week, the lower dosages are used with the gradual increase. The scheme of dosing is the following:
From the first to the third day of the therapy, the dosage should be 0.5 mg taken one time per day.
From the fourth to the seventh day the dosage should be 0.5 mg taken two times a day.
From the day eight until the end of the therapy the dose should be 1 mg taken two times a day.
Before starting the treatment, you need to establish the date when you want to quit smoking completely. Then you should order Chantix and start using it for one to two weeks before the set date.
If the adverse effects related to the medication use are intense, the daily dose can be temporarily or permanently lowered to 0.5 mg taken twice a day.
The pills must be swallowed entirely without chewing or crushing. The treatment should be made within twelve days. People who quit smoking during these twelve days can use the drug for more twelve weeks at the dose of 1 mg taken twice a day.
There is no information on the efficiency of an additional course in individuals who couldn’t manage to quit smoking within the first twelve weeks.
What side effects can the medication provoke?
When you order Generic Chantix, you should be aware that it can cause certain adverse effects. For instance, the most common adverse effects of the drug are nausea and vivid dreams.
Other less common adverse effects are a headache, depression, insomnia, and others. However, some of them are considered to be related to the smoking cessation rather than the effects of the medicine.
In case of the development of any skin reactions such as rash or swelling, the use of the medication must be discontinued immediately as these allergic reactions can develop to a life-threatening form.
What happens if you overdose?
There are no documented cases of the overdose of the drug. However, if you significantly overdosed and start suffering from adverse effects, you need to seek medical assistance and receive symptomatic treatment.
Interactions with other drugs
There are no clinically significant interactions of Chantix known to date. However, the physiological changes that occur after the smoking cessation can influence the pharmacokinetics or pharmacodynamics of some drugs, which may require correction of their dose (eg: theophylline, warfarin, and insulin). Since smoking induces the isoenzyme CYP1A2, quitting can lead to an increase in the concentration of substrates of this isoenzyme in the blood plasma.
In the simultaneous use of the drug with the nicotine patches, the lowering of the blood pressure and the higher likelihood of adverse effects of both medications is noticed.
The safety and efficiency of Chantix with other smoking cessation aids had not been studied.
If you suffer from any serious conditions that require the constant use of any medications, make sure to talk to your doctor about the safety of their combination with Chantix before you order Varenicline even though you can do that without a prescription, it would be wiser to consult a doctor for your own safety.
Where can you buy Chantix cheap?
It’s not a secret that the same medicines are very differently priced in different countries. If it happens so that this particular drug is much more expensive in your country than in our, you can order Generic Varenicline from our online pharmacy and enjoy quite a significant saving.
We ship all medications including Chantix all over the world. You can get acquainted with the terms and cost of delivery when you press the button “buy” near the number of pills you plan to purchase. If you have any questions, you can always consult our pharmacists.
Our doctor prescribes Varenicline online for free, and there is no doctor’s consultation fee.
All orders of Varenicline arrive in discrete unmarked parcels. We leave the shipment description blank.